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Literature DB >> 20674856

Our unindicted coconspirators: human metabolism from a microbial perspective.

Abstract

The human gut is populated by a microbiota composed of tens of trillions of organisms and millions of genes that together form a metabolic "organ." Intra- and interpersonal differences in the structure and functions of this organ suggest that it could contribute to our normal metabolic variations and also to metabolic disorders. This Commentary discusses experimental approaches for connecting microbial and host metabolism in the context of health and disease. Copyright 2010 Elsevier Inc. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20674856 PMCID： PMC2935662 DOI： 10.1016/j.cmet.2010.07.001

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

24 in total

1. Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins.

Authors: Peter J Turnbaugh; Christopher Quince; Jeremiah J Faith; Alice C McHardy; Tanya Yatsunenko; Faheem Niazi; Jason Affourtit; Michael Egholm; Bernard Henrissat; Rob Knight; Jeffrey I Gordon
Journal: Proc Natl Acad Sci U S A Date: 2010-04-02 Impact factor: 11.205

2. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.

Authors: William R Wikoff; Andrew T Anfora; Jun Liu; Peter G Schultz; Scott A Lesley; Eric C Peters; Gary Siuzdak
Journal: Proc Natl Acad Sci U S A Date: 2009-02-20 Impact factor: 11.205

3. Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.

Authors: Peter A Crawford; Jan R Crowley; Nandakumar Sambandam; Brian D Muegge; Elizabeth K Costello; Micah Hamady; Rob Knight; Jeffrey I Gordon
Journal: Proc Natl Acad Sci U S A Date: 2009-06-22 Impact factor: 11.205

4. Large-scale reconstruction and phylogenetic analysis of metabolic environments.

Authors: Elhanan Borenstein; Martin Kupiec; Marcus W Feldman; Eytan Ruppin
Journal: Proc Natl Acad Sci U S A Date: 2008-09-11 Impact factor: 11.205

5. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.

Authors: T Andrew Clayton; David Baker; John C Lindon; Jeremy R Everett; Jeremy K Nicholson
Journal: Proc Natl Acad Sci U S A Date: 2009-08-10 Impact factor: 11.205

6. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.

Authors: Buck S Samuel; Abdullah Shaito; Toshiyuki Motoike; Federico E Rey; Fredrik Backhed; Jill K Manchester; Robert E Hammer; S Clay Williams; Jan Crowley; Masashi Yanagisawa; Jeffrey I Gordon
Journal: Proc Natl Acad Sci U S A Date: 2008-10-17 Impact factor: 11.205

Review 7. Bile acids as regulatory molecules.

Authors: Phillip B Hylemon; Huiping Zhou; William M Pandak; Shunlin Ren; Gregorio Gil; Paul Dent
Journal: J Lipid Res Date: 2009-04-03 Impact factor: 5.922

8. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.

Authors: Sandrine P Claus; Tsz M Tsang; Yulan Wang; Olivier Cloarec; Eleni Skordi; François-Pierre Martin; Serge Rezzi; Alastair Ross; Sunil Kochhar; Elaine Holmes; Jeremy K Nicholson
Journal: Mol Syst Biol Date: 2008-10-14 Impact factor: 11.429

9. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.

Authors: François-Pierre J Martin; Marc-Emmanuel Dumas; Yulan Wang; Cristina Legido-Quigley; Ivan K S Yap; Huiru Tang; Séverine Zirah; Gerard M Murphy; Olivier Cloarec; John C Lindon; Norbert Sprenger; Laurent B Fay; Sunil Kochhar; Peter van Bladeren; Elaine Holmes; Jeremy K Nicholson
Journal: Mol Syst Biol Date: 2007-05-22 Impact factor: 11.429

10. A core gut microbiome in obese and lean twins.

Authors: Peter J Turnbaugh; Micah Hamady; Tanya Yatsunenko; Brandi L Cantarel; Alexis Duncan; Ruth E Ley; Mitchell L Sogin; William J Jones; Bruce A Roe; Jason P Affourtit; Michael Egholm; Bernard Henrissat; Andrew C Heath; Rob Knight; Jeffrey I Gordon
Journal: Nature Date: 2008-11-30 Impact factor: 49.962

31 in total

1. Bacterial secretion comes of age.

Authors: Gabriel Waksman
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2012-04-19 Impact factor: 6.237

Review 2. Experimental approaches for defining functional roles of microbes in the human gut.

Authors: Gautam Dantas; Morten O A Sommer; Patrick H Degnan; Andrew L Goodman
Journal: Annu Rev Microbiol Date: 2013 Impact factor: 15.500

3. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.

Authors: Aleksandar D Kostic; Dirk Gevers; Chandra Sekhar Pedamallu; Monia Michaud; Fujiko Duke; Ashlee M Earl; Akinyemi I Ojesina; Joonil Jung; Adam J Bass; Josep Tabernero; José Baselga; Chen Liu; Ramesh A Shivdasani; Shuji Ogino; Bruce W Birren; Curtis Huttenhower; Wendy S Garrett; Matthew Meyerson
Journal: Genome Res Date: 2011-10-18 Impact factor: 9.043

Our unindicted coconspirators: human metabolism from a microbial perspective.

1. Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins.

2. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.

3. Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.

4. Large-scale reconstruction and phylogenetic analysis of metabolic environments.

5. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.

6. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.

Review 7. Bile acids as regulatory molecules.

8. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.

9. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.

10. A core gut microbiome in obese and lean twins.

1. Bacterial secretion comes of age.

Review 2. Experimental approaches for defining functional roles of microbes in the human gut.

3. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.

4. Considerations When Designing a Microbiome Study: Implications for Nursing Science.

5. Digging deeper into obesity.

6. Culturable gut microbiota diversity in zebrafish.

7. The microbiota and HIV: shedding light on dark matters.

8. Phascolarctobacterium faecium abundant colonization in human gastrointestinal tract.

Review 9. The gastrointestinal tumor microenvironment.

Review 10. Metaorganismal nutrient metabolism as a basis of cardiovascular disease.