Literature DB >> 20674573

The role of telomeres and telomerase in stem cell aging.

Ignacio Flores1, Maria A Blasco.   

Abstract

Stem cells regenerate our bodies. In a similar manner to match ignition, stem cell "ignition" has to be precisely tuned to avoid uncontrolled proliferation as may occur in tumors or, inversely, the lack of proliferation as happens in degenerative disorders. During the last years it has become evident that telomeres and telomerase are main components of the stem cell "ignition" mechanism, providing a way to restrain cancer and delay aging. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20674573     DOI： 10.1016/j.febslet.2010.07.042

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  51 in total

1.  Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms.

Authors:  Thomas C J Tan; Ruman Rahman; Farah Jaber-Hijazi; Daniel A Felix; Chen Chen; Edward J Louis; Aziz Aboobaker
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-27       Impact factor: 11.205

Review 2.  Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair.

Authors:  Bin Yao; Sha Huang; Dongyun Gao; Jiangfan Xie; Nanbo Liu; Xiaobing Fu
Journal:  Int Wound J       Date:  2015-10-01       Impact factor: 3.315

Review 3.  Stem cell therapy for neurological disorders: A focus on aging.

Authors:  Hung Nguyen; Sydney Zarriello; Alexandreya Coats; Cannon Nelson; Chase Kingsbury; Anna Gorsky; Mira Rajani; Elliot G Neal; Cesar V Borlongan
Journal:  Neurobiol Dis       Date:  2018-09-13       Impact factor: 5.996

Review 4.  The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease.

Authors:  Michael Hadjiargyrou; Regis J O'Keefe
Journal:  J Bone Miner Res       Date:  2014-11       Impact factor: 6.741

5.  Genetic instability of modified stem cells - a first step towards malignant transformation?

Authors:  Doris Steinemann; Gudrun Göhring; Brigitte Schlegelberger
Journal:  Am J Stem Cells       Date:  2013-03-08

6.  Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.

Authors:  M Kucia; D-M Shin; R Liu; J Ratajczak; E Bryndza; M M Masternak; A Bartke; M Z Ratajczak
Journal:  Leukemia       Date:  2011-05-13       Impact factor: 11.528

7.  Sigma-2 receptor as potential indicator of stem cell differentiation.

Authors:  Jodi L Haller; Irina Panyutin; Aneeka Chaudhry; Chenbo Zeng; Robert H Mach; Joseph A Frank
Journal:  Mol Imaging Biol       Date:  2012-06       Impact factor: 3.488

8.  The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).

Authors:  Magda Kucia; Michal Masternak; Riu Liu; Dong-Myung Shin; Janina Ratajczak; Katarzyna Mierzejewska; Adam Spong; John J Kopchick; Andrzej Bartke; Mariusz Z Ratajczak
Journal:  Age (Dordr)       Date:  2012-01-05

9.  Adipose-derived mesenchymal stromal cells from aged patients with coronary artery disease keep mesenchymal stromal cell properties but exhibit characteristics of aging and have impaired angiogenic potential.

Authors:  Anastasia Efimenko; Nina Dzhoyashvili; Natalia Kalinina; Tatiana Kochegura; Renat Akchurin; Vsevolod Tkachuk; Yelena Parfyonova
Journal:  Stem Cells Transl Med       Date:  2013-12-18       Impact factor: 6.940

10.  Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.

Authors:  Radmila Hrdlicková; Jirí Nehyba; Henry R Bose
Journal:  Mol Cell Biol       Date:  2012-08-20       Impact factor: 4.272
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