BACKGROUND: Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality. METHODS: We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls. RESULTS: NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata. CONCLUSIONS: Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.
BACKGROUND:Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality. METHODS: We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLEpatients without NPSLE, and twenty age- and gender-matched controls. RESULTS: NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata. CONCLUSIONS: Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.
Authors: E M Tan; A S Cohen; J F Fries; A T Masi; D J McShane; N F Rothfield; J G Schaller; N Talal; R J Winchester Journal: Arthritis Rheum Date: 1982-11
Authors: Meggan Mackay; An Vo; Chris C Tang; Michael Small; Erik W Anderson; Elisabeth J Ploran; Justin Storbeck; Brittany Bascetta; Simran Kang; Cynthia Aranow; Carl Sartori; Philip Watson; Bruce T Volpe; Betty Diamond; David Eidelberg Journal: JCI Insight Date: 2019-01-10
Authors: Diogo G Corrêa; Nicolle Zimmermann; Rafael S Borges; Denis B Pereira; Thomas M Doring; Gustavo Tukamoto; Rochele P Fonseca; Emerson L Gasparetto Journal: Neuroradiol J Date: 2018-08-09
Authors: Ece Ercan; Cesar Magro-Checa; Romain Valabregue; Francesca Branzoli; Emily T Wood; Gerda M Steup-Beekman; Andrew G Webb; Tom W J Huizinga; Mark A van Buchem; Itamar Ronen Journal: Brain Date: 2016-03-11 Impact factor: 13.501
Authors: S J Wiseman; M E Bastin; I F Hamilton; D Hunt; S J Ritchie; E N Amft; S Thomson; J F F Belch; S H Ralston; J M Wardlaw Journal: Lupus Date: 2016-09-29 Impact factor: 2.911