Randall W Burt1. 1. Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA. randall.burt@hci.utah.edu
Abstract
PURPOSE OF REVIEW: The review will summarize the state of the art in colon cancer screening. Recently published screening guidelines will be reviewed so physicians can understand them and how to deal with the differences. Each screening modality presently in use will then be reviewed with emphasis on efficacy and problems. RECENT FINDINGS: During the past two decades research has clearly demonstrated colon cancer screening to be effective. New modalities such as virtual colonoscopy and stool DNA screening have been introduced and are recommended by some organizations but not others. Ages to discontinue screening have also been suggested. Fecal immunochemical testing exhibits some advantages over guaiac-based testing. Problematic issues with the effectiveness of colonoscopy have arisen, particularly in the proximal colon. Both technical and biological reasons have been suggested for this decrease in effectiveness. SUMMARY: Colon cancer screening is effective and continues to improve. Refinements of guidelines as well as refinements in each screening modality have occurred. Several screening tools are newly available and quality studies and efforts for present and new tests are imperative.
PURPOSE OF REVIEW: The review will summarize the state of the art in colon cancer screening. Recently published screening guidelines will be reviewed so physicians can understand them and how to deal with the differences. Each screening modality presently in use will then be reviewed with emphasis on efficacy and problems. RECENT FINDINGS: During the past two decades research has clearly demonstrated colon cancer screening to be effective. New modalities such as virtual colonoscopy and stool DNA screening have been introduced and are recommended by some organizations but not others. Ages to discontinue screening have also been suggested. Fecal immunochemical testing exhibits some advantages over guaiac-based testing. Problematic issues with the effectiveness of colonoscopy have arisen, particularly in the proximal colon. Both technical and biological reasons have been suggested for this decrease in effectiveness. SUMMARY:Colon cancer screening is effective and continues to improve. Refinements of guidelines as well as refinements in each screening modality have occurred. Several screening tools are newly available and quality studies and efforts for present and new tests are imperative.
Authors: Gregory A Abel; Christopher R Friese; Bridget A Neville; Katherine M Wilson; B Taylor Hastings; Craig C Earle; Nancy L Keating; Lisa C Richardson Journal: Am J Hematol Date: 2012-03-31 Impact factor: 10.047
Authors: Hyae Min Lee; Jae Myung Cha; Jung Lok Lee; Jung Won Jeon; Hyun Phil Shin; Kwang Ro Joo; Jin Young Yoon; Joung Il Lee Journal: Intest Res Date: 2017-10-23
Authors: Xavier Solé; Marta Crous-Bou; David Cordero; David Olivares; Elisabet Guinó; Rebeca Sanz-Pamplona; Francisco Rodriguez-Moranta; Xavier Sanjuan; Javier de Oca; Ramon Salazar; Victor Moreno Journal: PLoS One Date: 2014-09-12 Impact factor: 3.240