OBJECTIVE: To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis. DESIGN: Retrospective cohort study. SETTING: University-based infertility center, January 1998 to June 2006. PATIENT(S): Two hundred eighteen IVF pregnancies after fresh embryo transfer (ET); 122 IVF pregnancies after frozen ET. INTERVENTION(S): Assessment of perinatal outcome in fresh versus frozen ET pregnancies. MAIN OUTCOME MEASURE(S): Pregnancy outcomes after fresh versus frozen embryo transfer (ET). Primary outcome was a composite of three events: preterm delivery, intrauterine growth restriction, or low birth weight. Secondary outcomes were subtypes of pregnancy loss. Associations were assessed using multivariate logistic regression. RESULT(S): The final sample included 340 pregnancies: 218 fresh and 122 frozen ETs. Singleton pregnancy was less likely after transfer of fresh embryos (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.23-0.67), and pregnancies after fresh ET were more likely to end in first-trimester loss (OR 1.82, 95% CI 1.05-3.13). Composite adverse outcome after transfer of fresh (44.0%) versus frozen (32.6%) embryos was higher (OR 1.52, 95% CI 0.90-2.56) and was strongly associated with twin gestation (OR 23.82, 95% CI 11.16-50.82). CONCLUSION(S): Perinatal morbidity is higher in IVF pregnancies conceived after a fresh ET compared with a frozen ET. Although some differences are related to conception with twin gestations, these findings suggest that adverse outcomes may be related to differences in IVF procedures.
OBJECTIVE: To study the association of perinatal outcome and IVF transfer type in a group of infertilitypatients with standardized treatment and similar prognosis. DESIGN: Retrospective cohort study. SETTING: University-based infertility center, January 1998 to June 2006. PATIENT(S): Two hundred eighteen IVF pregnancies after fresh embryo transfer (ET); 122 IVF pregnancies after frozen ET. INTERVENTION(S): Assessment of perinatal outcome in fresh versus frozen ET pregnancies. MAIN OUTCOME MEASURE(S): Pregnancy outcomes after fresh versus frozen embryo transfer (ET). Primary outcome was a composite of three events: preterm delivery, intrauterine growth restriction, or low birth weight. Secondary outcomes were subtypes of pregnancy loss. Associations were assessed using multivariate logistic regression. RESULT(S): The final sample included 340 pregnancies: 218 fresh and 122 frozen ETs. Singleton pregnancy was less likely after transfer of fresh embryos (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.23-0.67), and pregnancies after fresh ET were more likely to end in first-trimester loss (OR 1.82, 95% CI 1.05-3.13). Composite adverse outcome after transfer of fresh (44.0%) versus frozen (32.6%) embryos was higher (OR 1.52, 95% CI 0.90-2.56) and was strongly associated with twin gestation (OR 23.82, 95% CI 11.16-50.82). CONCLUSION(S): Perinatal morbidity is higher in IVF pregnancies conceived after a fresh ET compared with a frozen ET. Although some differences are related to conception with twin gestations, these findings suggest that adverse outcomes may be related to differences in IVF procedures.
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Authors: R G Edwards; S B Fishel; J Cohen; C B Fehilly; J M Purdy; J M Slater; P C Steptoe; J M Webster Journal: J In Vitro Fert Embryo Transf Date: 1984-03
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Authors: Fatih Adanacıoğlu; Zeynep Gözde Tokat; Dürdane Büyükfidan; Hanifi M Özgül; Ferhat I Urunsak; Selahittin Çayan; Turan M Çetin Journal: Turk J Urol Date: 2019-12-01
Authors: Monica Mainigi; Jason M Rosenzweig; Jun Lei; Virginia Mensah; Lauren Thomaier; C Conover Talbot; Devvora Olalere; Teri Ord; Rayyan Rozzah; Michael V Johnston; Irina Burd Journal: Reprod Sci Date: 2015-11-26 Impact factor: 3.060