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Literature DB >> 20660668

Short cationic antimicrobial peptides interact with ATP.

Kai Hilpert¹, Brett McLeod, Jessie Yu, Melissa R Elliott, Marina Rautenbach, Serge Ruden, Jochen Bürck, Claudia Muhle-Goll, Anne S Ulrich, Sandro Keller, Robert E W Hancock.

Abstract

The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. α-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2010 PMID： 20660668 PMCID： PMC2944583 DOI： 10.1128/AAC.01664-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding.

Authors: G Kragol; S Lovas; G Varadi; B A Condie; R Hoffmann; L Otvos
Journal: Biochemistry Date: 2001-03-13 Impact factor: 3.162

Review 2. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

Authors: Kim A Brogden
Journal: Nat Rev Microbiol Date: 2005-03 Impact factor: 60.633

Review 3. The co-evolution of host cationic antimicrobial peptides and microbial resistance.

Authors: Andreas Peschel; Hans-Georg Sahl
Journal: Nat Rev Microbiol Date: 2006-06-12 Impact factor: 60.633

4. Sequence requirements and an optimization strategy for short antimicrobial peptides.

Authors: Kai Hilpert; Melissa R Elliott; Rudolf Volkmer-Engert; Peter Henklein; Oreola Donini; Qun Zhou; Dirk F H Winkler; Robert E W Hancock
Journal: Chem Biol Date: 2006-10

Review 5. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria.

Authors: John D F Hale; Robert E W Hancock
Journal: Expert Rev Anti Infect Ther Date: 2007-12 Impact factor: 5.091

6. High-throughput generation of small antibacterial peptides with improved activity.

Authors: Kai Hilpert; Rudolf Volkmer-Engert; Tess Walter; Robert E W Hancock
Journal: Nat Biotechnol Date: 2005-07-24 Impact factor: 54.908

7. Interaction of cationic antimicrobial peptides with model membranes.

Authors: L Zhang; A Rozek; R E Hancock
Journal: J Biol Chem Date: 2001-07-25 Impact factor: 5.157

8. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria.

Authors: C L Friedrich; D Moyles; T J Beveridge; R E Hancock
Journal: Antimicrob Agents Chemother Date: 2000-08 Impact factor: 5.191

9. Mechanism of antimicrobial action of indolicidin.

Authors: C Subbalakshmi; N Sitaram
Journal: FEMS Microbiol Lett Date: 1998-03-01 Impact factor: 2.742

10. Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli.

Authors: Aleksander Patrzykat; Carol L Friedrich; Lijuan Zhang; Valentina Mendoza; Robert E W Hancock
Journal: Antimicrob Agents Chemother Date: 2002-03 Impact factor: 5.191

28 in total

1. Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity.

Authors: A K Marr; S Cen; R E W Hancock; W R McMaster
Journal: Antimicrob Agents Chemother Date: 2016-03-25 Impact factor: 5.191

2. Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.

Authors: Christopher J Arnusch; Hannah Ulm; Michaele Josten; Yana Shadkchan; Nir Osherov; Hans-Georg Sahl; Yechiel Shai
Journal: Antimicrob Agents Chemother Date: 2011-10-17 Impact factor: 5.191

10. Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens.

Authors: Johannes Koehbach; Jurnorain Gani; Kai Hilpert; David J Craik
Journal: Microorganisms Date: 2021-06-08

Short cationic antimicrobial peptides interact with ATP.

1. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding.

Review 2. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

Review 3. The co-evolution of host cationic antimicrobial peptides and microbial resistance.

4. Sequence requirements and an optimization strategy for short antimicrobial peptides.

Review 5. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria.

6. High-throughput generation of small antibacterial peptides with improved activity.

7. Interaction of cationic antimicrobial peptides with model membranes.

8. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria.

9. Mechanism of antimicrobial action of indolicidin.

10. Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli.

1. Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity.

2. Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.

3. Additive and synergistic membrane permeabilization by antimicrobial (lipo)peptides and detergents.

4. Antibacterial Mode of Action of Ib-AMP1 Against Escherichia coli O157:H7.

5. Screening for antifungal peptides and their modes of action in Aspergillus nidulans.

6. Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.

7. Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogs.

8. Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides.

Review 9. Antibiofilm activity of host defence peptides: complexity provides opportunities.

10. Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens.