A Gastaldelli1, G Basta. 1. Institute of Clinical Physiology, National Research Council, CNR, Cardiometabolic Risk Unit, Via Moruzzi 1 Pisa 56100, Italy. amalia@ifc.cnr.it
Abstract
AIM: of this paper is to review the recent literature on the relationship between ectopic fat accumulation and cardiovascular disease. DATA SYNTHESIS: Ectopic fat is an important predictor of metabolic (in particular insulin resistance) and cardiovascular disease, carrying more risk than general fat accumulation. Recent studies have shown a link between ectopic fat accumulation, as cardiac (epicardial or intra-myocardial fat) and/or visceral and/or hepatic fat, and development of atherosclerosis, coronary heart disease and hypertension. CONCLUSIONS: Ectopic fat accumulation is not only a marker of cardiometabolic disease, since through the release of adipocitokines, lipotoxic and glucotoxic agents, participates in the crosstalk with insulin-sensitive organs leading to metabolic, cardiac and vascular dysfunctions. Copyright 2010 Elsevier B.V. All rights reserved.
AIM: of this paper is to review the recent literature on the relationship between ectopic fat accumulation and cardiovascular disease. DATA SYNTHESIS: Ectopic fat is an important predictor of metabolic (in particular insulin resistance) and cardiovascular disease, carrying more risk than general fat accumulation. Recent studies have shown a link between ectopic fat accumulation, as cardiac (epicardial or intra-myocardial fat) and/or visceral and/or hepatic fat, and development of atherosclerosis, coronary heart disease and hypertension. CONCLUSIONS: Ectopic fat accumulation is not only a marker of cardiometabolic disease, since through the release of adipocitokines, lipotoxic and glucotoxic agents, participates in the crosstalk with insulin-sensitive organs leading to metabolic, cardiac and vascular dysfunctions. Copyright 2010 Elsevier B.V. All rights reserved.
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