Literature DB >> 20655601

A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.

A J Ligocki1, L Lovato, D Xiang, P Guidry, R H Scheuermann, S N Willis, S Almendinger, M K Racke, E M Frohman, D A Hafler, K C O'Connor, N L Monson.   

Abstract

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20655601      PMCID： PMC2937103          DOI： 10.1016/j.jneuroim.2010.06.016

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  14 in total

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Review 3.  The B cell response in multiple sclerosis.

Authors:  Gregory P Owens; Jeffrey L Bennett; Donald H Gilden; Mark P Burgoon
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Review 4.  Roles of immunoglobulins and B cells in multiple sclerosis: from pathogenesis to treatment.

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Journal:  J Neuroimmunol       Date:  2006-08-23       Impact factor: 3.478

5.  Unveiling the enigma of the CNS as a B-cell fostering environment.

Authors:  Antonio Uccelli; Francesca Aloisi; Vito Pistoia
Journal:  Trends Immunol       Date:  2005-05       Impact factor: 16.687

Review 6.  The immunopathology of multiple sclerosis: an overview.

Authors:  Hans Lassmann; Wolfgang Brück; Claudia F Lucchinetti
Journal:  Brain Pathol       Date:  2007-04       Impact factor: 6.508

Review 7.  The pathology of MS: new insights and potential clinical applications.

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Authors:  H Lassmann; W Brück; C Lucchinetti
Journal:  Trends Mol Med       Date:  2001-03       Impact factor: 11.951

9.  Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.

Authors:  Barbara Serafini; Barbara Rosicarelli; Roberta Magliozzi; Egidio Stigliano; Francesca Aloisi
Journal:  Brain Pathol       Date:  2004-04       Impact factor: 6.508

10.  Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.

Authors:  Elizabeth M Cameron; Sade Spencer; Jonathan Lazarini; Christopher T Harp; E Sally Ward; Mark Burgoon; Gregory P Owens; Michael K Racke; Jeffrey L Bennett; Elliot M Frohman; Nancy L Monson
Journal:  J Neuroimmunol       Date:  2009-07-24       Impact factor: 3.478
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  9 in total

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Review 2.  B cells and antibodies in multiple sclerosis pathogenesis and therapy.

Authors:  Markus Krumbholz; Tobias Derfuss; Reinhard Hohlfeld; Edgar Meinl
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Authors:  Sarah B Simmons; Emily R Pierson; Sarah Y Lee; Joan M Goverman
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4.  Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.

Authors:  A J Ligocki; W H Rounds; E M Cameron; C T Harp; E M Frohman; A M Courtney; S Vernino; L G Cowell; B Greenberg; N L Monson
Journal:  Genes Immun       Date:  2013-04-18       Impact factor: 2.676

Review 5.  B cells in MS and NMO: pathogenesis and therapy.

Authors:  Markus Krumbholz; Edgar Meinl
Journal:  Semin Immunopathol       Date:  2014-05-16       Impact factor: 9.623

Review 6.  Intrathecal IgG synthesis: a resistant and valuable target for future multiple sclerosis treatments.

Authors:  Mickael Bonnan
Journal:  Mult Scler Int       Date:  2015-01-08

7.  The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.

Authors:  William H Rounds; Ann J Ligocki; Mikhail K Levin; Benjamin M Greenberg; Douglas W Bigwood; Eric M Eastman; Lindsay G Cowell; Nancy L Monson
Journal:  Front Neurol       Date:  2014-09-16       Impact factor: 4.003

8.  A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients.

Authors:  Ann J Ligocki; Jacqueline R Rivas; William H Rounds; Alyssa A Guzman; Min Li; Melania Spadaro; Lauren Lahey; Ding Chen; Paul M Henson; Donna Graves; Benjamin M Greenberg; Elliot M Frohman; E Sally Ward; William Robinson; Edgar Meinl; Charles L White; Ann M Stowe; Nancy L Monson
Journal:  ASN Neuro       Date:  2015-10-21       Impact factor: 4.146

9.  Sequencing the immunopathologic heterogeneity in multiple sclerosis.

Authors:  Jack P Antel; Samuel K Ludwin; Amit Bar-Or
Journal:  Ann Clin Transl Neurol       Date:  2015-09       Impact factor: 4.511
  9 in total

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