Literature DB >> 19631394

Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.

Elizabeth M Cameron1, Sade Spencer, Jonathan Lazarini, Christopher T Harp, E Sally Ward, Mark Burgoon, Gregory P Owens, Michael K Racke, Jeffrey L Bennett, Elliot M Frohman, Nancy L Monson.   

Abstract

We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.

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Year:  2009        PMID： 19631394      PMCID： PMC2785005          DOI： 10.1016/j.jneuroim.2009.05.014

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  58 in total

1.  Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.

Authors:  Gregory P Owens; Alanna M Ritchie; Mark P Burgoon; R Anthony Williamson; John R Corboy; Donald H Gilden
Journal:  J Immunol       Date:  2003-09-01       Impact factor: 5.422

Review 2.  B-cells in multiple sclerosis.

Authors:  M Duddy; A Bar-Or
Journal:  Int MS J       Date:  2006-11

Review 3.  Multiple sclerosis--the plaque and its pathogenesis.

Authors:  Elliot M Frohman; Michael K Racke; Cedric S Raine
Journal:  N Engl J Med       Date:  2006-03-02       Impact factor: 91.245

4.  CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome.

Authors:  Jeffrey L Bennett; Kurt Haubold; Alanna M Ritchie; Sydni J Edwards; Mark Burgoon; Andrew J Shearer; Donald H Gilden; Gregory P Owens
Journal:  J Neuroimmunol       Date:  2008-06-10       Impact factor: 3.478

5.  Delineation of selective influences shaping the mutated expressed human Ig heavy chain repertoire.

Authors:  T Dörner; H P Brezinschek; S J Foster; R I Brezinschek; N L Farner; P E Lipsky
Journal:  J Immunol       Date:  1998-03-15       Impact factor: 5.422

6.  Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis.

Authors:  Olaf Stüve; Sabine Cepok; Birte Elias; Andreas Saleh; Hans-Peter Hartung; Bernhard Hemmer; Bernd C Kieseier
Journal:  Arch Neurol       Date:  2005-10

7.  B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions.

Authors:  S E Baranzini; M C Jeong; C Butunoi; R S Murray; C C Bernard; J R Oksenberg
Journal:  J Immunol       Date:  1999-11-01       Impact factor: 5.422

Review 8.  Use of immunoglobulin variable-region genes by normal subjects and patients with systemic lupus erythematosus.

Authors:  A Hansen; T Dörner; P E Lipsky
Journal:  Int Arch Allergy Immunol       Date:  2000-09       Impact factor: 2.749

9.  Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

Authors:  Y Qin; P Duquette; Y Zhang; P Talbot; R Poole; J Antel
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808

10.  Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis.

Authors:  W I McDonald; A Compston; G Edan; D Goodkin; H P Hartung; F D Lublin; H F McFarland; D W Paty; C H Polman; S C Reingold; M Sandberg-Wollheim; W Sibley; A Thompson; S van den Noort; B Y Weinshenker; J S Wolinsky
Journal:  Ann Neurol       Date:  2001-07       Impact factor: 10.422
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  21 in total

Review 1.  Viruses and multiple sclerosis.

Authors:  Gregory P Owens; Don Gilden; Mark P Burgoon; Xiaoli Yu; Jeffrey L Bennett
Journal:  Neuroscientist       Date:  2011-12       Impact factor: 7.519

2.  Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing.

Authors:  Jason A Vander Heiden; Panos Stathopoulos; Julian Q Zhou; Luan Chen; Tamara J Gilbert; Christopher R Bolen; Richard J Barohn; Mazen M Dimachkie; Emma Ciafaloni; Teresa J Broering; Francois Vigneault; Richard J Nowak; Steven H Kleinstein; Kevin C O'Connor
Journal:  J Immunol       Date:  2017-01-13       Impact factor: 5.422

3.  MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing.

Authors:  William H Rounds; Edward A Salinas; Tom B Wilks; Mikhail K Levin; Ann J Ligocki; Carolina Ionete; Carlos A Pardo; Steven Vernino; Benjamin M Greenberg; Douglas W Bigwood; Eric M Eastman; Lindsay G Cowell; Nancy L Monson
Journal:  Gene       Date:  2015-07-11       Impact factor: 3.688

4.  Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.

Authors:  Jacqueline R Rivas; Sara J Ireland; Rati Chkheidze; William H Rounds; Joseph Lim; Jordan Johnson; Denise M O Ramirez; Ann J Ligocki; Ding Chen; Alyssa A Guzman; Mark Woodhall; Patrick C Wilson; Eric Meffre; Charles White; Benjamin M Greenberg; Patrick Waters; Lindsay G Cowell; Ann M Stowe; Nancy L Monson
Journal:  Acta Neuropathol       Date:  2016-10-11       Impact factor: 17.088

5.  A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.

Authors:  A J Ligocki; L Lovato; D Xiang; P Guidry; R H Scheuermann; S N Willis; S Almendinger; M K Racke; E M Frohman; D A Hafler; K C O'Connor; N L Monson
Journal:  J Neuroimmunol       Date:  2010-07-23       Impact factor: 3.478

Review 6.  Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future.

Authors:  Itay Raphael; Johanna Webb; Olaf Stuve; William Haskins; Thomas Forsthuber
Journal:  Expert Rev Clin Immunol       Date:  2014-12-18       Impact factor: 4.473

Review 7.  B cells and antibodies in multiple sclerosis pathogenesis and therapy.

Authors:  Markus Krumbholz; Tobias Derfuss; Reinhard Hohlfeld; Edgar Meinl
Journal:  Nat Rev Neurol       Date:  2012-10-09       Impact factor: 42.937

8.  Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.

Authors:  A J Ligocki; W H Rounds; E M Cameron; C T Harp; E M Frohman; A M Courtney; S Vernino; L G Cowell; B Greenberg; N L Monson
Journal:  Genes Immun       Date:  2013-04-18       Impact factor: 2.676

9.  Elevated CNS inflammation in patients with preclinical Alzheimer's disease.

Authors:  Nancy L Monson; Sara J Ireland; Ann J Ligocki; Ding Chen; William H Rounds; Min Li; Ryan M Huebinger; C Munro Cullum; Benjamin M Greenberg; Ann M Stowe; Rong Zhang
Journal:  J Cereb Blood Flow Metab       Date:  2013-10-23       Impact factor: 6.200

Review 10.  B cells in MS and NMO: pathogenesis and therapy.

Authors:  Markus Krumbholz; Edgar Meinl
Journal:  Semin Immunopathol       Date:  2014-05-16       Impact factor: 9.623
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