Literature DB >> 20655462

SRD5A3: A surprising role in glycosylation.

Ashlee R Stiles1, David W Russell.   

Abstract

The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease. Copyright 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20655462      PMCID： PMC3104503          DOI： 10.1016/j.cell.2010.07.003

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

1.  Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.

Authors:  Young-Ah Moon; Jay D Horton
Journal:  J Biol Chem       Date:  2002-12-13       Impact factor: 5.157

2.  Conservation of function between mammalian and plant steroid 5alpha-reductases.

Authors:  J Li; M G Biswas; A Chao; D W Russell; J Chory
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

Review 3.  Sexual differentiation.

Authors:  J D Wilson
Journal:  Annu Rev Physiol       Date:  1978       Impact factor: 19.318

Review 4.  Steroid 5 alpha-reductase: two genes/two enzymes.

Authors:  D W Russell; J D Wilson
Journal:  Annu Rev Biochem       Date:  1994       Impact factor: 23.643

5.  SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.

Authors:  Vincent Cantagrel; Dirk J Lefeber; Bobby G Ng; Ziqiang Guan; Jennifer L Silhavy; Stephanie L Bielas; Ludwig Lehle; Hans Hombauer; Maciej Adamowicz; Ewa Swiezewska; Arjan P De Brouwer; Peter Blümel; Jolanta Sykut-Cegielska; Scott Houliston; Dominika Swistun; Bassam R Ali; William B Dobyns; Dusica Babovic-Vuksanovic; Hans van Bokhoven; Ron A Wevers; Christian R H Raetz; Hudson H Freeze; Eva Morava; Lihadh Al-Gazali; Joseph G Gleeson
Journal:  Cell       Date:  2010-07-15       Impact factor: 41.582

6.  Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer.

Authors:  Motohide Uemura; Kenji Tamura; Suyoun Chung; Seijiro Honma; Akihiko Okuyama; Yusuke Nakamura; Hidewaki Nakagawa
Journal:  Cancer Sci       Date:  2007-11-06       Impact factor: 6.716

Review 7.  Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase.

Authors:  Valérie S Langlois; Dapeng Zhang; Gerard M Cooke; Vance L Trudeau
Journal:  Gen Comp Endocrinol       Date:  2009-08-15       Impact factor: 2.822
  7 in total
  20 in total

Review 1.  Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?

Authors:  Abdulmaged M Traish; Roberto Cosimo Melcangi; Marco Bortolato; Luis M Garcia-Segura; Michael Zitzmann
Journal:  Rev Endocr Metab Disord       Date:  2015-09       Impact factor: 6.514

2.  Expression in Escherichia Coli, Purification, and Functional Reconstitution of Human Steroid 5α-Reductases.

Authors:  Hwei-Ming Peng; Juan Valentín-Goyco; Sang-Choul Im; Bing Han; Jiayan Liu; Jie Qiao; Richard J Auchus
Journal:  Endocrinology       Date:  2020-08-01       Impact factor: 4.736

Review 3.  Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.

Authors:  Lina Schiffer; Lise Barnard; Elizabeth S Baranowski; Lorna C Gilligan; Angela E Taylor; Wiebke Arlt; Cedric H L Shackleton; Karl-Heinz Storbeck
Journal:  J Steroid Biochem Mol Biol       Date:  2019-07-27       Impact factor: 4.292

4.  GlycA: A New Biomarker for Systemic Inflammation and Cardiovascular Disease (CVD) Risk Assessment.

Authors:  Rami A Ballout; Alan T Remaley
Journal:  J Lab Precis Med       Date:  2020-04-20

Review 5.  Minireview: Androgen metabolism in castration-resistant prostate cancer.

Authors:  Nima Sharifi
Journal:  Mol Endocrinol       Date:  2013-04-16

6.  Timing of prenatal exposure to trauma and altered placental expressions of hypothalamic-pituitary-adrenal axis genes and genes driving neurodevelopment.

Authors:  W Zhang; Q Li; M Deyssenroth; L Lambertini; J Finik; J Ham; Y Huang; K J Tsuchiya; P Pehme; J Buthmann; S Yoshida; J Chen; Y Nomura
Journal:  J Neuroendocrinol       Date:  2018-04       Impact factor: 3.627

7.  Androgenic to oestrogenic switch in the human adult prostate gland is regulated by epigenetic silencing of steroid 5α-reductase 2.

Authors:  Zongwei Wang; Libing Hu; Keyan Salari; Seth K Bechis; Rongbin Ge; Shulin Wu; Cyrus Rassoulian; Jonathan Pham; Chin-Lee Wu; Shahin Tabatabaei; Douglas W Strand; Aria F Olumi
Journal:  J Pathol       Date:  2017-12       Impact factor: 7.996

Review 8.  Understanding human glycosylation disorders: biochemistry leads the charge.

Authors:  Hudson H Freeze
Journal:  J Biol Chem       Date:  2013-01-17       Impact factor: 5.157

9.  NF-κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.

Authors:  David C Austin; Douglas W Strand; Harold L Love; Omar E Franco; Magdalena M Grabowska; Nicole L Miller; Omar Hameed; Peter E Clark; Robert J Matusik; Ren J Jin; Simon W Hayward
Journal:  Prostate       Date:  2016-05-16       Impact factor: 4.104

10.  Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice.

Authors:  Sara H Windahl; Niklas Andersson; Anna E Börjesson; Charlotte Swanson; Johan Svensson; Sofia Movérare-Skrtic; Klara Sjögren; Ruijin Shao; Marie K Lagerquist; Claes Ohlsson
Journal:  PLoS One       Date:  2011-06-22       Impact factor: 3.240
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