| Literature DB >> 20655217 |
Leslie N Aldrich1, Sydney L Stoops, Brenda C Crews, Lawrence J Marnett, Craig W Lindsley.
Abstract
Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20655217 DOI： 10.1016/j.bmcl.2010.06.154
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823