OBJECTIVE: L-3-[¹⁸F]-fluoro-α-methyl tyrosine (FAMT) is transported into cancer cells by L: -type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate the uptake of FAMT and FDG with the cellular proliferative activity measured by the Ki-67 labeling index (Ki-67 LI) in oral squamous cell carcinoma (OSCC). METHODS: Twenty-five patients with OSCC were enrolled in this study. Both FAMT-PET and FDG-PET were performed within 4 weeks before surgery in all cases. The uptake of FAMT and FDG was compared by semiquantitative analysis with maximal standardized uptake values (SUVmax) of the primary tumors. Ki-67 LI of the tumors was analyzed by immunohistochemical staining and correlated with the clinicopathologic variables and the uptake of PET tracers. RESULTS: For primary tumor detection, FAMT-PET exhibited a sensitivity of 84%, whereas that of FDG-PET was 88%. In all visible lesions, mean FDG uptake determined by average SUVmax was 9.7 (range 4.2-15.9) and mean FAMT uptake was 3.5 (range 1.3-8.5). The SUVmax of FAMT tended to show a better correlation with Ki-67 LI (r = 0.878) than that of FDG (r = 0.643). CONCLUSIONS: Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation of OSCC.
OBJECTIVE: L-3-[¹⁸F]-fluoro-α-methyl tyrosine (FAMT) is transported into cancer cells by L: -type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate the uptake of FAMT and FDG with the cellular proliferative activity measured by the Ki-67 labeling index (Ki-67 LI) in oral squamous cell carcinoma (OSCC). METHODS: Twenty-five patients with OSCC were enrolled in this study. Both FAMT-PET and FDG-PET were performed within 4 weeks before surgery in all cases. The uptake of FAMT and FDG was compared by semiquantitative analysis with maximal standardized uptake values (SUVmax) of the primary tumors. Ki-67 LI of the tumors was analyzed by immunohistochemical staining and correlated with the clinicopathologic variables and the uptake of PET tracers. RESULTS: For primary tumor detection, FAMT-PET exhibited a sensitivity of 84%, whereas that of FDG-PET was 88%. In all visible lesions, mean FDG uptake determined by average SUVmax was 9.7 (range 4.2-15.9) and mean FAMT uptake was 3.5 (range 1.3-8.5). The SUVmax of FAMT tended to show a better correlation with Ki-67 LI (r = 0.878) than that of FDG (r = 0.643). CONCLUSIONS: Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation of OSCC.
Authors: Delphine Denoyer; Laura Kirby; Kelly Waldeck; Peter Roselt; Oliver C Neels; Thomas Bourdier; Rachael Shepherd; Andrew Katsifis; Rodney J Hicks Journal: Eur J Nucl Med Mol Imaging Date: 2011-12-13 Impact factor: 9.236
Authors: I-Hong Shih; Fan-Lin Kong; Mohammad S Ali; Yinhan Zhang; Dong-Fang Yu; Xudong Duan; David J Yang Journal: Biomed Res Int Date: 2013-07-09 Impact factor: 3.411
Authors: S Suzuki; K Kaira; Y Ohshima; N S Ishioka; M Sohda; T Yokobori; T Miyazaki; N Oriuchi; H Tominaga; Y Kanai; N Tsukamoto; T Asao; Y Tsushima; T Higuchi; T Oyama; H Kuwano Journal: Br J Cancer Date: 2014-03-25 Impact factor: 7.640
Authors: S Kito; H Koga; M Kodama; M Habu; S Kokuryo; M Oda; K Matsuo; T Nishino; S Matsumoto-Takeda; M Uehara; D Yoshiga; T Tanaka; S Nishimura; I Miyamoto; M Sasaguri; K Tominaga; I Yoshioka; Y Morimoto Journal: Med Oral Patol Oral Cir Bucal Date: 2016-05-01