| Literature DB >> 20651736 |
Jane Trepel1, Mehdi Mollapour, Giuseppe Giaccone, Len Neckers.
Abstract
The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to facilitate the function of numerous oncoproteins, and it can be argued that cancer cells are 'addicted' to HSP90. However, although recent reports of the early clinical efficacy of HSP90 inhibitors are encouraging, the optimal use of HSP90-targeted therapeutics will depend on understanding the complexity of HSP90 regulation and the degree to which HSP90 participates in both neoplastic and normal cellular physiology.Entities:
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Year: 2010 PMID： 20651736 PMCID： PMC6778733 DOI： 10.1038/nrc2887
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716