| Literature DB >> 20650639 |
Fernanda M F Roleira1, Christophe Siquet, Elizabeta Orrù, E Manuela Garrido, Jorge Garrido, Nuno Milhazes, Gianni Podda, Fátima Paiva-Martins, Salette Reis, Rui A Carvalho, Elisiário J Tavares da Silva, Fernanda Borges.
Abstract
Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation between the redox potentials and the antioxidant activity. In addition, some compounds showed a proper lipophilicity to cross the blood-brain barrier. Their predicted ADME properties are also in accordance with the general requirements for potential CNS drugs. Accordingly, one can propose these phenolic compounds as potential antioxidants for tackling the oxidative status linked to the neurodegenerative processes. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20650639 DOI： 10.1016/j.bmc.2010.06.090
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641