James M O'Brien1, Scott K Aberegg, Naeem A Ali, Gregory B Diette, Stanley Lemeshow. 1. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA. james.obrien@osumc.edu
Abstract
PURPOSE: We sought to evaluate factors associated with choices about provided care for patients with septic shock, including the use of drotrecogin α (activated) (DAA). MATERIALS AND METHODS: We administered a mail-based survey to a random sample of intensivists. Study vignettes presented patients with septic shock with identical severity of illness scores but different ages, body mass indices, and comorbidities. Respondents estimated outcomes and selected care beyond standardized initial care (eg, antibiotics) for each hypothetical patient. RESULTS: For most vignettes (99.1%), respondents added care, most commonly low tidal volume ventilation (87.6%) and enteral nutrition (73.3%). Choosing to administer DAA was not associated with predictions about mortality or bleeding. Vignettes with early-stage lung cancer were less likely to receive DAA. Time since medical school graduation was also associated with lower odds of selecting DAA. Most respondents (52.6%) chose identical care for all 4 completed vignettes. CONCLUSIONS: There was wide variability in the therapeutic choices of respondents. The use of DAA was not associated with perceived risk of mortality or bleeding, as recommended by consensus guidelines. Physicians appear to base treatment decisions in septic shock on a consistent pattern of practice rather than estimates of patient outcome.
PURPOSE: We sought to evaluate factors associated with choices about provided care for patients with septic shock, including the use of drotrecogin α (activated) (DAA). MATERIALS AND METHODS: We administered a mail-based survey to a random sample of intensivists. Study vignettes presented patients with septic shock with identical severity of illness scores but different ages, body mass indices, and comorbidities. Respondents estimated outcomes and selected care beyond standardized initial care (eg, antibiotics) for each hypothetical patient. RESULTS: For most vignettes (99.1%), respondents added care, most commonly low tidal volume ventilation (87.6%) and enteral nutrition (73.3%). Choosing to administer DAA was not associated with predictions about mortality or bleeding. Vignettes with early-stage lung cancer were less likely to receive DAA. Time since medical school graduation was also associated with lower odds of selecting DAA. Most respondents (52.6%) chose identical care for all 4 completed vignettes. CONCLUSIONS: There was wide variability in the therapeutic choices of respondents. The use of DAA was not associated with perceived risk of mortality or bleeding, as recommended by consensus guidelines. Physicians appear to base treatment decisions in septic shock on a consistent pattern of practice rather than estimates of patient outcome.
Authors: Ricard Ferrer; Antonio Artigas; David Suarez; Eduardo Palencia; Mitchell M Levy; Angel Arenzana; Xose Luis Pérez; Josep-Maria Sirvent Journal: Am J Respir Crit Care Med Date: 2009-08-20 Impact factor: 21.405
Authors: E Wesley Ely; Pierre-François Laterre; Derek C Angus; Jeffrey D Helterbrand; Howard Levy; Jean-François Dhainaut; Jean-Louis Vincent; William L Macias; Gordon R Bernard Journal: Crit Care Med Date: 2003-01 Impact factor: 7.598
Authors: D Tony Yu; Edgar Black; Kenneth E Sands; J Sanford Schwartz; Patricia L Hibberd; Paul S Graman; Paul N Lanken; Katherine L Kahn; David R Snydman; Jeffrey Parsonnet; Richard Moore; Richard Platt; David W Bates Journal: Crit Care Date: 2003-03-17 Impact factor: 9.097
Authors: Gordon R Bernard; William L Macias; David E Joyce; Mark D Williams; Joan Bailey; Jean-Louis Vincent Journal: Crit Care Date: 2003-02-28 Impact factor: 9.097