OBJECTIVES: To investigate the association between cardiopulmonary fitness and cognitive performance in subjects with coronary artery disease (CAD). DESIGN: Cross-sectional observational study. SETTING: Outpatient cardiac rehabilitation. PARTICIPANTS: Eighty-one subjects with CAD. MEASUREMENTS: Cardiopulmonary fitness was assessed by measuring peak oxygen uptake (VO(2Peak) ) in a standardized exercise stress test. The fraction of the predicted age and sex norm for VO(2Peak) was computed for each patient. A battery of neuropsychological tests including the Stroop, Trail-Making Test Part B, Digit Symbol Coding, Revised Brief Visuospatial Memory Test, California Verbal Learning Test 2nd Edition, and Mini Mental State Examination (MMSE) was administered, from which composite Z-scores were computed for tasks involving executive function and memory. RESULTS: Executive function, memory, and MMSE scores were correlated with VO(2Peak) , but only performance in the executive domain was independently associated with VO(2Peak) in multiple linear regression. In a multiple linear regression model controlling for potential clinical confounders, VO(2Peak) (β=.666, P<.001) and covariates accounted for 36% of the variance in executive function scores. CONCLUSION: Poorer VO(2Peak) is associated with poorer cognition, particularly executive function, in subjects with CAD independent of other cardiac risk factors. Cardiopulmonary fitness may be a protective factor for cognition in patients with CAD.
OBJECTIVES: To investigate the association between cardiopulmonary fitness and cognitive performance in subjects with coronary artery disease (CAD). DESIGN: Cross-sectional observational study. SETTING:Outpatient cardiac rehabilitation. PARTICIPANTS: Eighty-one subjects with CAD. MEASUREMENTS: Cardiopulmonary fitness was assessed by measuring peak oxygen uptake (VO(2Peak) ) in a standardized exercise stress test. The fraction of the predicted age and sex norm for VO(2Peak) was computed for each patient. A battery of neuropsychological tests including the Stroop, Trail-Making Test Part B, Digit Symbol Coding, Revised Brief Visuospatial Memory Test, California Verbal Learning Test 2nd Edition, and Mini Mental State Examination (MMSE) was administered, from which composite Z-scores were computed for tasks involving executive function and memory. RESULTS: Executive function, memory, and MMSE scores were correlated with VO(2Peak) , but only performance in the executive domain was independently associated with VO(2Peak) in multiple linear regression. In a multiple linear regression model controlling for potential clinical confounders, VO(2Peak) (β=.666, P<.001) and covariates accounted for 36% of the variance in executive function scores. CONCLUSION: Poorer VO(2Peak) is associated with poorer cognition, particularly executive function, in subjects with CAD independent of other cardiac risk factors. Cardiopulmonary fitness may be a protective factor for cognition in patients with CAD.
Authors: Daniel E Forman; Ross Arena; Rebecca Boxer; Mary A Dolansky; Janice J Eng; Jerome L Fleg; Mark Haykowsky; Arshad Jahangir; Leonard A Kaminsky; Dalane W Kitzman; Eldrin F Lewis; Jonathan Myers; Gordon R Reeves; Win-Kuang Shen Journal: Circulation Date: 2017-03-23 Impact factor: 29.690
Authors: W Swardfager; N Herrmann; S Marzolini; M Saleem; P Shammi; P I Oh; P R Albert; M Daigle; A Kiss; K L Lanctôt Journal: Brain Behav Immun Date: 2011-04-30 Impact factor: 7.217
Authors: Mark Mapstone; Tiffany N Hilton; Hongmei Yang; Joseph J Guido; Amneris E Luque; William J Hall; Stephen Dewhurst; Krupa Shah Journal: Aging Dis Date: 2013-08-27 Impact factor: 6.745
Authors: Mahwesh Saleem; Veera V Ratnam Bandaru; Nathan Herrmann; Walter Swardfager; Michelle M Mielke; Paul I Oh; Prathiba Shammi; Alexander Kiss; Norman J Haughey; Randal Rovinski; Krista L Lanctôt Journal: BMC Geriatr Date: 2013-12-12 Impact factor: 3.921
Authors: Ivonne Suridjan; Nathan Herrmann; Alex Adibfar; Mahwesh Saleem; Ana Andreazza; Paul I Oh; Krista L Lanctôt Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Mahwesh Saleem; Nathan Herrmann; Walter Swardfager; Paul I Oh; Prathiba Shammi; Gideon Koren; Stan Van Uum; Alexander Kiss; Krista L Lanctôt Journal: Cardiovasc Psychiatry Neurol Date: 2013-01-16