PURPOSE: To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy. RESULTS: Observed allelic frequencies were: TSER, (2) 0.54 and (3) 0.46; MTHFR C677T, (C) 0.59 and (T) 0.41; p53 Arg72Pro, (Arg) 0.73 and (Pro) 0.27; MDR1 C3435T, (C) 0.52 and (T) 0.48. MTHFR allele T and p53 allele Pro were strongly associated with toxicity due to chemotherapy (odds ratio, 7.1 (95% confidence interval, 1.4-36.1; p=0.018) and 7.0 (95% confidence interval, 1.2-40.5; p=0.029), respectively). CONCLUSION: We introduced new data related to the contribution of p53 codon 72 to toxicity due to 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy in patients with breast cancer.
PURPOSE: To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancerpatients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy. RESULTS: Observed allelic frequencies were: TSER, (2) 0.54 and (3) 0.46; MTHFRC677T, (C) 0.59 and (T) 0.41; p53Arg72Pro, (Arg) 0.73 and (Pro) 0.27; MDR1C3435T, (C) 0.52 and (T) 0.48. MTHFR allele T and p53 allele Pro were strongly associated with toxicity due to chemotherapy (odds ratio, 7.1 (95% confidence interval, 1.4-36.1; p=0.018) and 7.0 (95% confidence interval, 1.2-40.5; p=0.029), respectively). CONCLUSION: We introduced new data related to the contribution of p53 codon 72 to toxicity due to 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy in patients with breast cancer.
Authors: Mary D Chamberlin; Jason D Wells; Kevin Shee; Jennifer R Bean; Jonathan D Marotti; Wendy A Wells; Heidi W Trask; Fred W Kolling; Ananta Bhatt; Peter A Kaufman; Gary N Schwartz; John M Gemery; Nancy J McNulty; Michael J Tsapakos; Richard J Barth; Bradley A Arrick; Jiang Gui; Todd W Miller Journal: Breast Cancer Res Treat Date: 2020-06-19 Impact factor: 4.872
Authors: Vinayak W Patil; Mukund B Tayade; Sangeeta A Pingale; Shubhangi M Dalvi; Rajesh B Rajekar; Hemkant M Deshmukh; Shital D Patil; Rajeev Singhai Journal: Breast Cancer (Dove Med Press) Date: 2011-08-11
Authors: Luis Alberto Henríquez-Hernández; Almudena Valenciano; Palmira Foro-Arnalot; María Jesús Alvarez-Cubero; José Manuel Cozar; José Francisco Suárez-Novo; Manel Castells-Esteve; Adriana Ayala-Gil; Pablo Fernández-Gonzalo; Montse Ferrer; Ferrán Guedea; Gemma Sancho-Pardo; Jordi Craven-Bartle; María José Ortiz-Gordillo; Patricia Cabrera-Roldán; Estefanía Herrera-Ramos; Pedro C Lara Journal: PLoS One Date: 2013-07-23 Impact factor: 3.240