Literature DB >> 20634903

Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.

Amos B Smith1, Onur Atasoylu, Douglas C Beshore.   

Abstract

An efficient protocol for elaboration of the 5,6-fused 2-pyridone ring system, exploiting the tandem condensation of propiolamide and cyclic β-ketomethyl esters in water, followed by acid or base promoted intramolecular ring closure and decarboxylation, has been developed.

Entities:  

Year:  2009        PMID： 20634903      PMCID： PMC2904244          DOI： 10.1055/s-0029-1217749

Source DB:  PubMed          Journal:  Synlett        ISSN： 0936-5214            Impact factor:   2.454


  5 in total

1.  Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.

Authors:  K Högenauer; K Baumann; A Enz; J Mulzer
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2.  Total syntheses of (+)-lyconadin A and (-)-lyconadin B.

Authors:  Douglas C Beshore; Amos B Smith
Journal:  J Am Chem Soc       Date:  2007-03-17       Impact factor: 15.419

Review 3.  Camptothecin and taxol: discovery to clinic.

Authors:  M E Wall
Journal:  Med Res Rev       Date:  1998-09       Impact factor: 12.944

4.  Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.

Authors:  B E Evans; K E Rittle; M G Bock; R M DiPardo; R M Freidinger; W L Whitter; G F Lundell; D F Veber; P S Anderson; R S Chang
Journal:  J Med Chem       Date:  1988-12       Impact factor: 7.446

5.  Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.

Authors:  G Campiani; A P Kozikowski; S Wang; L Ming; V Nacci; A Saxena; B P Doctor
Journal:  Bioorg Med Chem Lett       Date:  1998-06-02       Impact factor: 2.823
  5 in total
  4 in total

1.  Pyridone annulation via tandem Curtius rearrangement/6π-electrocyclization: total synthesis of (-)-lyconadin C.

Authors:  Xiayun Cheng; Stephen P Waters
Journal:  Org Lett       Date:  2013-08-02       Impact factor: 6.005

2.  Total Syntheses of Lyconadins: Finding Efficiency and Diversity.

Authors:  Yang Yang; Mingji Dai
Journal:  Synlett       Date:  2014       Impact factor: 2.454

3.  Michael Reaction of 3-aAryl-2,4-Dicarboethoxy-5-Hydroxy-5-Methylcyclohexanones.

Authors:  Fawzia Zakaria El-Ablack; M A Metwally; A M Khalil
Journal:  Org Chem Int       Date:  2015-09-01

4.  l-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety via sustainable sonochemical approach.

Authors:  Hamada Mohamed Ibrahim; Wael Abdelgayed Ahmed Arafa; Haider Behbehani
Journal:  RSC Adv       Date:  2018-11-08       Impact factor: 4.036
  4 in total

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