Literature DB >> 11551765

Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.

K Högenauer1, K Baumann, A Enz, J Mulzer.   

Abstract

(E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivatives showed AChE inhibition constants in the low micromolar range and thus display better activity than all previously synthesized C5 derivatives.

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Year:  2001        PMID： 11551765     DOI： 10.1016/s0960-894x(01)00518-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.

Authors:  Amos B Smith; Onur Atasoylu; Douglas C Beshore
Journal:  Synlett       Date:  2009-01-01       Impact factor: 2.454

2.  Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization Fourier transform mass spectrometry.

Authors:  Zhe Xu; Shengjun Yao; Yuanlong Wei; Jing Zhou; Li Zhang; Cuihong Wang; Yinlong Guo
Journal:  J Am Soc Mass Spectrom       Date:  2008-08-15       Impact factor: 3.109

3.  The lyconadins: enantioselective total syntheses of (+)-lyconadin A and (-)-lyconadin B.

Authors:  Douglas C Beshore; Amos B Smith
Journal:  J Am Chem Soc       Date:  2008-09-18       Impact factor: 15.419

4.  Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors.

Authors:  Bruna R de Lima; Juliana M Lima; Jéssica B Maciel; Carolina Q Valentim; Rita de Cássia S Nunomura; Emerson S Lima; Hector H F Koolen; Afonso Duarte L de Souza; Maria Lúcia B Pinheiro; Quezia B Cass; Felipe Moura A da Silva
Journal:  Front Chem       Date:  2019-09-18       Impact factor: 5.221
  4 in total

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