BACKGROUND AND AIMS: Metabolic syndrome (MetS) comprises central obesity, insulin resistance, hypertension and dyslipidemia, interrelated metabolic risk factors for diabetes and cardiovascular disease. A state of low-grade systemic inflammation may underlie this constellation of risk factors. Chronic inflammatory conditions, such as periodontal disease, may contribute to systemic inflammation and development of MetS. This study examines the association of periodontitis with MetS with and without consideration of systemic inflammatory status. METHODS: The association of alveolar bone loss (none/slight vs moderate/severe) determined from panoramic radiographs and MetS parameters were analyzed using logistic regression, adjusting for age, sex, ethnicity, and smoking in 112 men and 78 women (mean+/-SD age 56.7+/-13.3 and 60.0+/-12.1, respectively) participating in the Baltimore Longitudinal Study of Aging. RESULTS: Participants with radiographic evidence of moderate to advanced alveolar bone loss were significantly more likely to have MetS than those with minimal or no bone loss (OR 2.61, 95% CI 1.1-6.1, p<0.05). No significant differences in systemic inflammation were found between periodontal groups. CONCLUSIONS: The association of alveolar bone loss to MetS is consistent with the hypothesis that destructive periodontal disease may contribute to the development of MetS and elevations in systemic inflammation. Longitudinal studies are necessary to clarify the role of periodontal disease in the development of MetS and conditions associated with chronic inflammation.
BACKGROUND AND AIMS: Metabolic syndrome (MetS) comprises central obesity, insulin resistance, hypertension and dyslipidemia, interrelated metabolic risk factors for diabetes and cardiovascular disease. A state of low-grade systemic inflammation may underlie this constellation of risk factors. Chronic inflammatory conditions, such as periodontal disease, may contribute to systemic inflammation and development of MetS. This study examines the association of periodontitis with MetS with and without consideration of systemic inflammatory status. METHODS: The association of alveolar bone loss (none/slight vs moderate/severe) determined from panoramic radiographs and MetS parameters were analyzed using logistic regression, adjusting for age, sex, ethnicity, and smoking in 112 men and 78 women (mean+/-SD age 56.7+/-13.3 and 60.0+/-12.1, respectively) participating in the Baltimore Longitudinal Study of Aging. RESULTS:Participants with radiographic evidence of moderate to advanced alveolar bone loss were significantly more likely to have MetS than those with minimal or no bone loss (OR 2.61, 95% CI 1.1-6.1, p<0.05). No significant differences in systemic inflammation were found between periodontal groups. CONCLUSIONS: The association of alveolar bone loss to MetS is consistent with the hypothesis that destructive periodontal disease may contribute to the development of MetS and elevations in systemic inflammation. Longitudinal studies are necessary to clarify the role of periodontal disease in the development of MetS and conditions associated with chronic inflammation.
Authors: Angelo Scuteri; Samer S Najjar; Denis C Muller; Reubin Andres; Hidetaka Hougaku; E Jeffrey Metter; Edward G Lakatta Journal: J Am Coll Cardiol Date: 2004-04-21 Impact factor: 24.094
Authors: Salomon Amar; Noyan Gokce; Sonia Morgan; Mariana Loukideli; Thomas E Van Dyke; Joseph A Vita Journal: Arterioscler Thromb Vasc Biol Date: 2003-05-22 Impact factor: 8.311
Authors: Isaac Suzart Gomes-Filho; Izadora da S C E Balinha; Simone S da Cruz; Soraya C Trindade; Eneida de M M Cerqueira; Johelle de S Passos-Soares; Julita Maria F Coelho; Ana Marice T Ladeia; Maria Isabel P Vianna; Alexandre M Hintz; Teresinha C de Santana; Pedro P Dos Santos; Ana Claúdia M G Figueiredo; Ivana C O da Silva; Frank A Scannapieco; Maurício L Barreto; Peter M Loomer Journal: Clin Oral Investig Date: 2020-11-23 Impact factor: 3.573
Authors: Maximiliano Schünke Gomes; Fernando Neves Hugo; Juliana Balbinot Hilgert; Dalva Maria Pereira Padilha; Eleanor Marie Simonsick; Luigi Ferrucci; Mark Allan Reynolds Journal: J Endod Date: 2012-03-21 Impact factor: 4.171
Authors: M S Gomes; F N Hugo; J B Hilgert; M Sant'Ana Filho; D M P Padilha; E M Simonsick; L Ferrucci; M A Reynolds Journal: Int Endod J Date: 2015-06-11 Impact factor: 5.264