| Literature DB >> 20633382 |
Walter Paulus1, Joseph Classen, Leonardo G Cohen, Charles H Large, Vincenzo Di Lazzaro, Michael Nitsche, Alvaro Pascual-Leone, F Rosenow, John C Rothwell, Ulf Ziemann.
Abstract
The combination of brain stimulation techniques like transcranial magnetic stimulation (TMS) with CNS active drugs in humans now offers a unique opportunity to explore the physiologic effects of these substances in vivo in the human brain. Motor threshold, motor evoked potential size, motor evoked potential intensity curves, cortical silent period, short-interval intracortical inhibition, intracortical facilitation, short-interval intracortical facilitation, long-interval intracortical inhibition and short latency afferent inhibition represent the repertoire for investigating drug effects on motor cortical excitability by TMS. Here we present an updated overview on the pharmacophysiologic mechanisms with special emphasis on methodologic pitfalls and possible future developments or requirements.Entities:
Mesh：
Substances：
Year: 2008 PMID： 20633382 DOI： 10.1016/j.brs.2008.06.002
Source DB: PubMed Journal: Brain Stimul ISSN： 1876-4754 Impact factor: 8.955