| Literature DB >> 20630772 |
Yumi Yashiro-Ohtani1, Takuya Ohtani, Warren S Pear.
Abstract
Notch signaling plays multiple roles in T cell development. Following thymic entry, Notch signals are required to specify the T cell fate from a multipotent hematopoietic progenitor. At subsequent steps in early T cell development, Notch provides important differentiation, survival, proliferation and metabolic signals. This review focuses on the multiple functions of Notch in early T cell development, from T cell specification in the thymus through beta selection. Copyright 2010. Published by Elsevier Ltd.Mesh:
Substances:
Year: 2010 PMID: 20630772 DOI: 10.1016/j.smim.2010.04.015
Source DB: PubMed Journal: Semin Immunol ISSN: 1044-5323 Impact factor: 11.130