Literature DB >> 20630755

Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.

Franco Chimenti1, Bruna Bizzarri, Adriana Bolasco, Daniela Secci, Paola Chimenti, Arianna Granese, Simone Carradori, Daniela Rivanera, Alessandra Zicari, M Maddalena Scaltrito, Francesca Sisto.   

Abstract

N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20630755     DOI： 10.1016/j.bmcl.2010.06.048

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

2.  Anti-Helicobacter pylori activity of some newly synthesized derivatives of xanthone.

Authors:  Karolina Klesiewicz; Elżbieta Karczewska; Alicja Budak; Henryk Marona; Natalia Szkaradek
Journal:  J Antibiot (Tokyo)       Date:  2016-03-30       Impact factor: 2.649

3.  Anti-Helicobacter pylori activity and Structure-Activity Relationship study of 2-Alkylthio-5-(nitroaryl)-1,3,4-thiadiazole Derivatives.

Authors:  Ali Asadipour; Najmeh Edraki; Maryam Nakhjiri; Azadeh Yahya-Meymandi; Eskandar Alipour; Parastoo Saniee; Farideh Siavoshi; Abbas Shafiee; Alireza Foroumadi
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

4.  6-Methyl-2-oxo-N-(quinolin-6-yl)-2H-chromene-3-carboxamide: crystal structure and Hirshfeld surface analysis.

Authors:  Lígia R Gomes; John Nicolson Low; André Fonseca; Maria João Matos; Fernanda Borges
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-07-12

5.  Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives.

Authors:  Lígia R Gomes; John Nicolson Low; André Fonseca; Maria João Matos; Fernanda Borges
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-06-10

6.  One-pot preparation of 4-aryl-3-bromocoumarins from 4-aryl-2-propynoic acids with diaryliodonium salts, TBAB, and Na2S2O8.

Authors:  Teppei Sasaki; Katsuhiko Moriyama; Hideo Togo
Journal:  Beilstein J Org Chem       Date:  2018-02-05       Impact factor: 2.883

7.  Coumarin Derivatives Solvent-Free Synthesis under Microwave Irradiation over Heterogeneous Solid Catalysts.

Authors:  Souad Bouasla; Juan Amaro-Gahete; Dolores Esquivel; M Isabel López; César Jiménez-Sanchidrián; Mabrouk Teguiche; Francisco J Romero-Salguero
Journal:  Molecules       Date:  2017-11-28       Impact factor: 4.411

8.  Highly efficient catalyst-free domino conjugate addition, decarboxylation and esterification/amidation of coumarin carboxylic acid/esters with pyrazolones: a green chemistry approach.

Authors:  Shanta Raj Lakshmi; Vipin Singh; L Raju Chowhan
Journal:  RSC Adv       Date:  2020-04-06       Impact factor: 4.036

9.  Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives.

Authors:  Pen-Yuan Lin; Kuang-Sheng Yeh; Chien-Ling Su; Shiow-Yunn Sheu; Tiffany Chen; Keng-Liang Ou; Mei-Hsiang Lin; Lin-Wen Lee
Journal:  Molecules       Date:  2012-09-10       Impact factor: 4.411

10.  Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents.

Authors:  Maria J Matos; Saleta Vazquez-Rodriguez; Lourdes Santana; Eugenio Uriarte; Cristina Fuentes-Edfuf; Ysabel Santos; Angeles Muñoz-Crego
Journal:  Molecules       Date:  2013-01-24       Impact factor: 4.411
  10 in total

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