Literature DB >> 20629623

10-20 Joules as a neuromolecular quantum in medicinal chemistry: an alternative approach to myriad molecular pathways?

M A Persinger1.   

Abstract

The myriads of molecular pathways that have been measured to understand the physical bases of neuronal and other cellular functions have exceeded classical comprehension. In the tradition of Bohr and Schrodinger, the hypothesis is developed that molecular pathways are simply epiphenomenal transports of quanta with increments in the order of 10(-20) J. Experimental measurements of photon emissions from cell cultures and the serial steps of phosphorylation in general molecular pathways and transformations in chromophores supported this contention. This discrete value is also associated with action potentials, intersynaptic events, the biophysical bases of membrane potentials, the numbers of action potentials per cell from magnetic energy potential, and the interionic distances around membranes. Consideration of information as discrete increments of energy may allow greater experimental control and external intervention of pathways relevant to medicinal chemistry.

Mesh:

Year:  2010        PMID: 20629623     DOI: 10.2174/092986710791959701

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN: 0929-8673            Impact factor:   4.530


  8 in total

1.  Shifting wavelengths of ultraweak photon emissions from dying melanoma cells: their chemical enhancement and blocking are predicted by Cosic's theory of resonant recognition model for macromolecules.

Authors:  Blake T Dotta; Nirosha J Murugan; Lukasz M Karbowski; Robert M Lafrenie; Michael A Persinger
Journal:  Naturwissenschaften       Date:  2014-01-15

2.  Annual incidence of mortality related to hypertensive disease in Canada and associations with heliophysical parameters.

Authors:  Joseph M Caswell; Trevor N Carniello; Nirosha J Murugan
Journal:  Int J Biometeorol       Date:  2015-04-26       Impact factor: 3.787

3.  Correlations between U.S. county annual cancer incidence and population density.

Authors:  David Ae Vares; Linda S St-Pierre; Michael A Persinger
Journal:  Am J Cancer Res       Date:  2015-10-15       Impact factor: 6.166

4.  Brain electromagnetic activity and lightning: potentially congruent scale-invariant quantitative properties.

Authors:  Michael A Persinger
Journal:  Front Integr Neurosci       Date:  2012-05-15

5.  Inverse relationship between photon flux densities and nanotesla magnetic fields over cell aggregates: Quantitative evidence for energetic conservation.

Authors:  Michael A Persinger; Blake T Dotta; Lukasz M Karbowski; Nirosha J Murugan
Journal:  FEBS Open Bio       Date:  2015-05-04       Impact factor: 2.693

6.  Novel Cosic resonance (standing wave) solutions for components of the JAK-STAT cellular signaling pathway: A convergence of spectral density profiles.

Authors:  Lukasz M Karbowski; Nirosha J Murugan; Michael A Persinger
Journal:  FEBS Open Bio       Date:  2015-03-25       Impact factor: 2.693

7.  Functional neuroimaging of post-mortem tissue: lithium-pilocarpine seized rats express reduced brain mass and proportional reductions of left ventral cerebral theta spectral power.

Authors:  Nicolas Rouleau; Brady S Reive; Michael A Persinger
Journal:  Heliyon       Date:  2016-10-20

8.  Ultraweak Photon Emissions as a Non-Invasive, Early-Malignancy Detection Tool: An In Vitro and In Vivo Study.

Authors:  Nirosha J Murugan; Michael A Persinger; Lukasz M Karbowski; Blake T Dotta
Journal:  Cancers (Basel)       Date:  2020-04-18       Impact factor: 6.639

  8 in total

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