Literature DB >> 20629058

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

Paul M O'Neill1, Richard K Amewu, Gemma L Nixon, Fatima Bousejra ElGarah, Mathirut Mungthin, James Chadwick, Alison E Shone, Livia Vivas, Hollie Lander, Victoria Barton, Sant Muangnoicharoen, Patrick G Bray, Jill Davies, B Kevin Park, Sergio Wittlin, Reto Brun, Michael Preschel, Kesheng Zhang, Stephen A Ward.   

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Year:  2010        PMID： 20629058     DOI： 10.1002/anie.201001026

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  22 in total

Review 1.  Malaria medicines: a glass half full?

Authors:  Timothy N C Wells; Rob Hooft van Huijsduijnen; Wesley C Van Voorhis
Journal:  Nat Rev Drug Discov       Date:  2015-05-22       Impact factor: 84.694

2.  The activity of dispiro peroxides against Fasciola hepatica.

Authors:  Xiaofang Wang; Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2011-07-19       Impact factor: 2.823

3.  3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents.

Authors:  Charles E Schiaffo; Matthias Rottman; Sergio Wittlin; Patrick H Dussault
Journal:  ACS Med Chem Lett       Date:  2011-04-14       Impact factor: 4.345

4.  Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

Authors:  Daniela Miranda; Rita Capela; Inês S Albuquerque; Patrícia Meireles; Isa Paiva; Fátima Nogueira; Richard Amewu; Jiri Gut; Philip J Rosenthal; Rudi Oliveira; Maria M Mota; Rui Moreira; Francesc Marti; Miguel Prudêncio; Paul M O'Neill; Francisca Lopes
Journal:  ACS Med Chem Lett       Date:  2013-12-20       Impact factor: 4.345

5.  Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni.

Authors:  Carla Kirchhofer; Mireille Vargas; Olivier Braissant; Yuxiang Dong; Xiaofang Wang; Jonathan L Vennerstrom; Jennifer Keiser
Journal:  Acta Trop       Date:  2011-02-21       Impact factor: 3.112

Review 6.  Rearrangements of organic peroxides and related processes.

Authors:  Ivan A Yaremenko; Vera A Vil'; Dmitry V Demchuk; Alexander O Terent'ev
Journal:  Beilstein J Org Chem       Date:  2016-08-03       Impact factor: 2.883

Review 7.  Antimalarial drug discovery - approaches and progress towards new medicines.

Authors:  Erika L Flannery; Arnab K Chatterjee; Elizabeth A Winzeler
Journal:  Nat Rev Microbiol       Date:  2013-11-11       Impact factor: 60.633

8.  Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Authors:  Ian M Copple; Amy E Mercer; James Firman; Gail Donegan; Bram Herpers; Michael Hl Wong; James Chadwick; Andreia D Bringela; Maria L S Cristiano; Bob van de Water; Stephen A Ward; Paul M O'Neill; B Kevin Park
Journal:  Mol Med       Date:  2012-09-25       Impact factor: 6.354

9.  Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Authors:  Zhiyong Yu; James A Brannigan; David K Moss; A Marek Brzozowski; Anthony J Wilkinson; Anthony A Holder; Edward W Tate; Robin J Leatherbarrow
Journal:  J Med Chem       Date:  2012-10-15       Impact factor: 7.446

Review 10.  The global pipeline of new medicines for the control and elimination of malaria.

Authors:  Melinda P Anthony; Jeremy N Burrows; Stephan Duparc; Joerg J Moehrle; Timothy N C Wells
Journal:  Malar J       Date:  2012-09-07       Impact factor: 2.979
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