BACKGROUND: Despite the increasing use of positron emission tomography/computed tomography (PET/CT) in the management of patients with breast cancer, its role is yet to be defined. PATIENTS AND METHODS: We reviewed PET/CT scans carried out in breast cancer patients, the indication, concordance/discordance with other imaging and whether their use had altered patient management. RESULTS: PET/CT scans (233) were carried out in 122 patients between July 2004 and October 2008. Indications were as follows: staging (S) (91), response assessment (RA) (87), clarification (C) of findings on other imaging (32) and reassurance (ASS) (23). In the S group, positive scans were helpful in accurately defining the extent of disease and guided localised or systemic treatment. PET/CT was particularly useful for detecting lytic bone metastases. One-third of the scans was carried out for RA. PET/CT allowed early RA and in some cases appropriate discontinuation of ineffective treatment. PET/CT was used effectively for the clarification of indeterminate lesions on CT (18), magnetic resonance imaging (15) and bone scan (13). In the ASS group, all scans were negative. CONCLUSIONS: PET/CT is useful in accurately staging metastatic disease, assessing response to systemic treatment and clarifying equivocation on other imaging. Incorporation of PET/CT in these areas contributes to breast cancer management optimisation.
BACKGROUND: Despite the increasing use of positron emission tomography/computed tomography (PET/CT) in the management of patients with breast cancer, its role is yet to be defined. PATIENTS AND METHODS: We reviewed PET/CT scans carried out in breast cancerpatients, the indication, concordance/discordance with other imaging and whether their use had altered patient management. RESULTS: PET/CT scans (233) were carried out in 122 patients between July 2004 and October 2008. Indications were as follows: staging (S) (91), response assessment (RA) (87), clarification (C) of findings on other imaging (32) and reassurance (ASS) (23). In the S group, positive scans were helpful in accurately defining the extent of disease and guided localised or systemic treatment. PET/CT was particularly useful for detecting lytic bone metastases. One-third of the scans was carried out for RA. PET/CT allowed early RA and in some cases appropriate discontinuation of ineffective treatment. PET/CT was used effectively for the clarification of indeterminate lesions on CT (18), magnetic resonance imaging (15) and bone scan (13). In the ASS group, all scans were negative. CONCLUSIONS: PET/CT is useful in accurately staging metastatic disease, assessing response to systemic treatment and clarifying equivocation on other imaging. Incorporation of PET/CT in these areas contributes to breast cancer management optimisation.
Authors: C Riegger; J Herrmann; J Nagarajah; J Hecktor; S Kuemmel; F Otterbach; S Hahn; A Bockisch; T Lauenstein; G Antoch; T A Heusner Journal: Eur J Nucl Med Mol Imaging Date: 2012-03-06 Impact factor: 9.236
Authors: Yoannis Imbert-Fernandez; Brian F Clem; Julie O'Neal; Daniel A Kerr; Robert Spaulding; Lilibeth Lanceta; Amy L Clem; Sucheta Telang; Jason Chesney Journal: J Biol Chem Date: 2014-02-10 Impact factor: 5.157
Authors: Roberta Piva; Flavia Ticconi; Valentina Ceriani; Federica Scalorbi; Francesco Fiz; Selene Capitanio; Matteo Bauckneht; Giuseppe Cittadini; Gianmario Sambuceti; Silvia Morbelli Journal: Breast Cancer (Dove Med Press) Date: 2017-07-04