BACKGROUND: Serum chemokine CXC Ligand 16 (CXCL16) concentration is associated with atherosclerosis and CXCL16 expression may be influenced by the polymorphism, A181V. We established whether serum CXCL16 concentration or the A181V genotype is more strongly associated with atherosclerotic stroke and its associated risk factor, carotid atherosclerosis. METHODS: PCR-RFLP was used to genotype 244 atherosclerotic stroke patients (AS group), 153 stroke-free controls (patient controls) and 167 healthy controls. Serum CXCL16 concentration was determined for a subset of patients (n=135) and all controls. The same subset of patients was then examined using ultrasound to evaluate their carotid atherosclerotic lesions, including intima-media thickness (IMT), plaque stability and carotid plaque area (CPA). RESULTS: Compared with the patient controls and healthy controls, serum CXCL16 concentration was significantly increased in the AS group (P<0.05, and 0.01). It was also strongly associated with increased IMT, vulnerable plaque and increased CPA (P<0.05, <0.001, and <0.01). However, the CXCL16 A181V genotype distribution and allele frequencies showed no differences between AS and control groups, nor did it influence serum CXCL16 concentration. CONCLUSION: Serum CXCL16 concentration is significantly associated with atherosclerotic stroke and carotid atherosclerosis, suggesting that this biochemical test may be useful to identify patients at increased risk of atherosclerosis. Copyright 2010 Elsevier B.V. All rights reserved.
BACKGROUND: Serum chemokine CXC Ligand 16 (CXCL16) concentration is associated with atherosclerosis and CXCL16 expression may be influenced by the polymorphism, A181V. We established whether serum CXCL16 concentration or the A181V genotype is more strongly associated with atherosclerotic stroke and its associated risk factor, carotid atherosclerosis. METHODS: PCR-RFLP was used to genotype 244 atherosclerotic strokepatients (AS group), 153 stroke-free controls (patient controls) and 167 healthy controls. Serum CXCL16 concentration was determined for a subset of patients (n=135) and all controls. The same subset of patients was then examined using ultrasound to evaluate their carotid atherosclerotic lesions, including intima-media thickness (IMT), plaque stability and carotid plaque area (CPA). RESULTS: Compared with the patient controls and healthy controls, serum CXCL16 concentration was significantly increased in the AS group (P<0.05, and 0.01). It was also strongly associated with increased IMT, vulnerable plaque and increased CPA (P<0.05, <0.001, and <0.01). However, the CXCL16A181V genotype distribution and allele frequencies showed no differences between AS and control groups, nor did it influence serum CXCL16 concentration. CONCLUSION: Serum CXCL16 concentration is significantly associated with atherosclerotic stroke and carotid atherosclerosis, suggesting that this biochemical test may be useful to identify patients at increased risk of atherosclerosis. Copyright 2010 Elsevier B.V. All rights reserved.
Authors: L Turgunova; B Baidildina; Y Laryushina; B Koichubekov; A Turmukhambetova; L Akhmaltdinova Journal: Cardiol Res Pract Date: 2020-06-23 Impact factor: 1.866
Authors: Anna Dieden; Leone Malan; Catharina M C Mels; Leandi Lammertyn; Annemarie Wentzel; Peter M Nilsson; Petri Gudmundsson; Amra Jujic; Martin Magnusson Journal: Medicine (Baltimore) Date: 2021-05-21 Impact factor: 1.817
Authors: Jianhui Sun; Huacai Zhang; Di Liu; Li Cui; Qiang Wang; Lebin Gan; Dalin Wen; Jun Wang; Juan Du; Hong Huang; Anqiang Zhang; Jin Deng; Jianxin Jiang; Ling Zeng Journal: Front Genet Date: 2021-09-03 Impact factor: 4.599