| Literature DB >> 20621360 |
Setshaba D Khanye1, Gregory S Smith, Carmen Lategan, Peter J Smith, Jiri Gut, Philip J Rosenthal, Kelly Chibale.
Abstract
The reaction of thiosemicarbazones (TSCs) with [Au(I)(THT)Cl], THT=tetrahydrothiophene, has been investigated. The resulting gold(I) complexes have been characterized by a range of spectroscopic techniques: NMR spectroscopy, mass spectrometry, microanalysis and infrared spectroscopy. The in vitro antimalarial data for gold(I) TSC complexes suggests that coordination of gold(I) to TSCs enhanced their efficacy against the malaria parasite Plasmodium falciparum and their inhibition of the parasite cysteine protease falcipain-2. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20621360 DOI： 10.1016/j.jinorgbio.2010.06.005
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155