Literature DB >> 20617244

Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity.

Micah D Shepherd1, Madan K Kharel, Lili L Zhu, Steven G van Lanen, Jürgen Rohr.   

Abstract

In vivo and in vitro investigations of GilP and GilQ, two acyltransferases encoded by the gilvocarcin gene cluster, show that GilQ confers unique starter unit specificity when catalyzing an early as well as rate limiting step of gilvocarcin biosynthesis.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20617244     DOI： 10.1039/c0ob00036a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.

Authors:  Micah D Shepherd; Tao Liu; Carmen Méndez; Jose A Salas; Jürgen Rohr
Journal:  Appl Environ Microbiol       Date:  2010-11-12       Impact factor: 4.792

2.  Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway.

Authors:  Nidhi Tibrewal; Theresa E Downey; Steven G Van Lanen; Ehesan Ul Sharif; George A O'Doherty; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2012-07-19       Impact factor: 15.419

3.  The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis.

Authors:  Nicholas Noinaj; Mary A Bosserman; M Alexandra Schickli; Grzegorz Piszczek; Madan K Kharel; Pallab Pahari; Susan K Buchanan; Jürgen Rohr
Journal:  J Biol Chem       Date:  2011-05-10       Impact factor: 5.157

Review 4.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

5.  Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.

Authors:  Pallab Pahari; Madan K Kharel; Micah D Shepherd; Steven G van Lanen; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2011-12-23       Impact factor: 15.336

6.  Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.

Authors:  Nidhi Tibrewal; Pallab Pahari; Guojun Wang; Madan K Kharel; Caleb Morris; Theresa Downey; Yanpeng Hou; Tim S Bugni; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2012-10-29       Impact factor: 15.419
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.