OBJECTIVE: The association between polymorphisms in intron 1 of the fat mass and obesity associated gene (FTO) and obesity-related traits is one of the most robust associations reported for complex traits and is established both in adults and children. However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity. METHODS: This study is based on the 2,732 full-term neonates of the German GINI-plus and LISA-plus birth cohorts, for whom genotyping data on the FTO variants rs1558902 (T>A) or rs9935401 (G>A) were available. Children were followed from birth up to age 6 years. Up to 9 anthropometric measurements of BMI were obtained. Fractional-Polynomial-Generalized-Estimation-Equation modeling was used to assess developmental trends and their potential dependence on genotype status. RESULTS: We observed no evidence for BMI differences between genotypes of both variants for the first 3 years of life. However, from age 3 years onwards, we noted a higher BMI for the homozygous minor alleles carriers in comparison to the other two genotype groups. However, evidence for statistical significance was reached from the age of 4 years onwards. CONCLUSIONS: This is one of the first studies investigating in detail the development of BMI depending on FTO genotype between birth and the age of 6 years in a birth cohort not selected for the phenotype studied. We observed that the association between BMI and FTO genotype evolves gradually and becomes descriptively detectable from the age of 3 years onwards. Copyright (c) 2010 S. Karger AG, Basel.
OBJECTIVE: The association between polymorphisms in intron 1 of the fat mass and obesity associated gene (FTO) and obesity-related traits is one of the most robust associations reported for complex traits and is established both in adults and children. However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity. METHODS: This study is based on the 2,732 full-term neonates of the German GINI-plus and LISA-plus birth cohorts, for whom genotyping data on the FTO variants rs1558902 (T>A) or rs9935401 (G>A) were available. Children were followed from birth up to age 6 years. Up to 9 anthropometric measurements of BMI were obtained. Fractional-Polynomial-Generalized-Estimation-Equation modeling was used to assess developmental trends and their potential dependence on genotype status. RESULTS: We observed no evidence for BMI differences between genotypes of both variants for the first 3 years of life. However, from age 3 years onwards, we noted a higher BMI for the homozygous minor alleles carriers in comparison to the other two genotype groups. However, evidence for statistical significance was reached from the age of 4 years onwards. CONCLUSIONS: This is one of the first studies investigating in detail the development of BMI depending on FTO genotype between birth and the age of 6 years in a birth cohort not selected for the phenotype studied. We observed that the association between BMI and FTO genotype evolves gradually and becomes descriptively detectable from the age of 3 years onwards. Copyright (c) 2010 S. Karger AG, Basel.
Authors: Karri Silventoinen; Aline Jelenkovic; Reijo Sund; Yoon-Mi Hur; Yoshie Yokoyama; Chika Honda; Jacob vB Hjelmborg; Sören Möller; Syuichi Ooki; Sari Aaltonen; Fuling Ji; Feng Ning; Zengchang Pang; Esther Rebato; Andreas Busjahn; Christian Kandler; Kimberly J Saudino; Kerry L Jang; Wendy Cozen; Amie E Hwang; Thomas M Mack; Wenjing Gao; Canqing Yu; Liming Li; Robin P Corley; Brooke M Huibregtse; Kaare Christensen; Axel Skytthe; Kirsten O Kyvik; Catherine A Derom; Robert F Vlietinck; Ruth Jf Loos; Kauko Heikkilä; Jane Wardle; Clare H Llewellyn; Abigail Fisher; Tom A McAdams; Thalia C Eley; Alice M Gregory; Mingguang He; Xiaohu Ding; Morten Bjerregaard-Andersen; Henning Beck-Nielsen; Morten Sodemann; Adam D Tarnoki; David L Tarnoki; Maria A Stazi; Corrado Fagnani; Cristina D'Ippolito; Ariel Knafo-Noam; David Mankuta; Lior Abramson; S Alexandra Burt; Kelly L Klump; Judy L Silberg; Lindon J Eaves; Hermine H Maes; Robert F Krueger; Matt McGue; Shandell Pahlen; Margaret Gatz; David A Butler; Meike Bartels; Toos Cem van Beijsterveldt; Jeffrey M Craig; Richard Saffery; Duarte L Freitas; José Antonio Maia; Lise Dubois; Michel Boivin; Mara Brendgen; Ginette Dionne; Frank Vitaro; Nicholas G Martin; Sarah E Medland; Grant W Montgomery; Youngsook Chong; Gary E Swan; Ruth Krasnow; Patrik Ke Magnusson; Nancy L Pedersen; Per Tynelius; Paul Lichtenstein; Claire Ma Haworth; Robert Plomin; Gombojav Bayasgalan; Danshiitsoodol Narandalai; K Paige Harden; Elliot M Tucker-Drob; Sevgi Y Öncel; Fazil Aliev; Timothy Spector; Massimo Mangino; Genevieve Lachance; Laura A Baker; Catherine Tuvblad; Glen E Duncan; Dedra Buchwald; Gonneke Willemsen; Finn Rasmussen; Jack H Goldberg; Thorkild Ia Sørensen; Dorret I Boomsma; Jaakko Kaprio Journal: Am J Clin Nutr Date: 2016-07-13 Impact factor: 7.045
Authors: Shubhabrata Mukherjee; Stefan Walter; John S K Kauwe; Andrew J Saykin; David A Bennett; Eric B Larson; Paul K Crane; M Maria Glymour Journal: Alzheimers Dement Date: 2015-06-12 Impact factor: 21.566