Literature DB >> 20615698

5-Nitro-2-furoic acid hydrazones: design, synthesis and in vitro antimycobacterial evaluation against log and starved phase cultures.

Dharmarajan Sriram1, Perumal Yogeeswari, Devambatla Ravi Kumar Vyas, Palaniappan Senthilkumar, Pritesh Bhat, Madala Srividya.   

Abstract

Various 5-nitro-2-furoic acid hydrazones were synthesized and evaluated for in vitro activities against log and starved phase culture of two mycobacterial species and Mycobacterium tuberculosis (MTB) isocitrate lyase (ICL) enzyme inhibition studies. Among twenty one compounds, 5-nitro-N'-[(5-nitro-2-furyl)methylidene]-2-furohydrazide (4o) was found to be the most active compound in vitro with MICs of 2.65 and 10.64 microM against log- and starved-phase culture of MTB. Compound 4o also showed good enzyme inhibition of MTB ICL at 10 microM. The docking studies also confirmed the binding potential of the compounds at the ICL active site. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20615698     DOI： 10.1016/j.bmcl.2010.06.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

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Review 4.  Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy.

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Journal:  Metabolites       Date:  2021-02-02

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Journal:  RSC Adv       Date:  2022-02-10       Impact factor: 3.361

6.  A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

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Review 7.  Potential inhibitors for isocitrate lyase of Mycobacterium tuberculosis and non-M. tuberculosis: a summary.

Authors:  Yie-Vern Lee; Habibah A Wahab; Yee Siew Choong
Journal:  Biomed Res Int       Date:  2015-01-08       Impact factor: 3.411
  7 in total

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