| Literature DB >> 20614885 |
Matthias A Oberli1, Marco Tamborrini, Yu-Hsuan Tsai, Daniel B Werz, Tim Horlacher, Alexander Adibekian, Dominik Gauss, Heiko M Möller, Gerd Pluschke, Peter H Seeberger.
Abstract
The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20614885 DOI： 10.1021/ja104027w
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419