OBJECTIVES: The aim of this research paper was to investigate the hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice. METHODS: In the present study, the hepatoprotective and antioxidant effects of gallic acid were evaluated against paracetamol-induced hepatotoxicity in mice and compared with the silymarin, a standard hepatoprotective drug. The mice received a single dose of paracetamol (900 mg/kg body weight i.p.). Gallic acid (100 mg/kg body weight i.p.) and silymarin (25 mg/kg body weight i.p.) were administered 30 min after the injection of paracetamol. After 4 h, liver marker enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase) and inflammatory mediator tumour necrosis factor-alpha (TNF-alpha) were estimated in serum, while the lipid peroxidation and antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glutathione) were determined in liver homogenate of the control and experimental mice. KEY FINDINGS: Increased activities of liver marker enzymes and elevated TNF-alpha and lipid peroxidation levels were observed in mice exposed to paracetamol (P < 0.05), whereas the antioxidant status was found to be depleted (P < 0.05) when compared with the control group. However gallic acid treatment (100 mg/kg body weight i.p.) significantly reverses (P < 0.05) the above changes by its antioxidant action compared to the control group as observed in the paracetamol-challenged mice. CONCLUSIONS: The results clearly demonstrate that gallic acid possesses promising hepatoprotective effects.
OBJECTIVES: The aim of this research paper was to investigate the hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice. METHODS: In the present study, the hepatoprotective and antioxidant effects of gallic acid were evaluated against paracetamol-induced hepatotoxicity in mice and compared with the silymarin, a standard hepatoprotective drug. The mice received a single dose of paracetamol (900 mg/kg body weight i.p.). Gallic acid (100 mg/kg body weight i.p.) and silymarin (25 mg/kg body weight i.p.) were administered 30 min after the injection of paracetamol. After 4 h, liver marker enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase) and inflammatory mediator tumour necrosis factor-alpha (TNF-alpha) were estimated in serum, while the lipid peroxidation and antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glutathione) were determined in liver homogenate of the control and experimental mice. KEY FINDINGS: Increased activities of liver marker enzymes and elevated TNF-alpha and lipid peroxidation levels were observed in mice exposed to paracetamol (P < 0.05), whereas the antioxidant status was found to be depleted (P < 0.05) when compared with the control group. However gallic acid treatment (100 mg/kg body weight i.p.) significantly reverses (P < 0.05) the above changes by its antioxidant action compared to the control group as observed in the paracetamol-challenged mice. CONCLUSIONS: The results clearly demonstrate that gallic acid possesses promising hepatoprotective effects.
Authors: Eman Al-Sayed; Olli Martiskainen; Sayed H Seif el-Din; Abdel-Nasser A Sabra; Olfat A Hammam; Naglaa M El-Lakkany; Mohamed M Abdel-Daim Journal: Biomed Res Int Date: 2014-05-14 Impact factor: 3.411
Authors: Ya Ju Chang; Shih Lan Hsu; Yi Ting Liu; Yu Hsuan Lin; Ming Hui Lin; Shu Jung Huang; Ja-an Annie Ho; Li-Chen Wu Journal: PLoS One Date: 2015-03-27 Impact factor: 3.240
Authors: Amir Mohammad Kazemifar; Ali Akbar Hajaghamohammadi; Rasoul Samimi; Zohreh Alavi; Esmail Abbasi; Marjan Nasiri Asl Journal: Gastroenterology Res Date: 2012-09-20