| Literature DB >> 23800857 |
Sauvik Bhattacharyya1, Sk Milan Ahammed, Bishnu Pada Saha, Pulok K Mukherjee.
Abstract
Gallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl4)-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl4-induced group (P < 0.05 and P < 0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.Entities:
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Year: 2013 PMID： 23800857 PMCID： PMC3755146 DOI： 10.1208/s12249-013-9991-8
Source DB: PubMed Journal: AAPS PharmSciTech ISSN： 1530-9932 Impact factor: 3.246