OBJECTIVE: To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life. DESIGN: Cross-sectional study. SETTING: Four U.S. sites. PARTICIPANTS: Nine thousand three hundred forty-four women aged 65 and older (mean 71.6) who self-reported teenage, age 30, age 50, and late-life physical activity. MEASUREMENTS: Logistic regression was used to determine the association between physical activity status at each age and likelihood of cognitive impairment (modified Mini-Mental State Examination (mMMSE) score >1.5 standard deviations below the mean, mMMSE score</=22). Models were adjusted for age, education, marital status, diabetes mellitus, hypertension, depressive symptoms, smoking, and body mass index. RESULTS: Women who reported being physically active had a lower prevalence of cognitive impairment in late life than women who were inactive at each time (teenage: 8.5% vs 16.7%, adjusted odds ratio (AOR)=0.65, 95% confidence interval (CI)=0.53-0.80; age 30: 8.9% vs 12.0%, AOR=0.80, 95% CI=0.67-0.96); age 50: 8.5% vs 13.1%, AOR=0.71, 95% CI=0.59-0.85; old age: 8.2% vs 15.9%, AOR=0.74, 95% CI=0.61-0.91). When the four times were analyzed together, teenage physical activity was most strongly associated with lower odds of late-life cognitive impairment (OR=0.73, 95% CI=0.58-0.92). However, women who were physically inactive as teenagers and became active in later life had lower risk than those who remained inactive. CONCLUSIONS: Women who reported being physically active at any point over the life course, especially as teenagers, had a lower likelihood of cognitive impairment in late life. Interventions should promote physical activity early in life and throughout the life course.
OBJECTIVE: To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life. DESIGN: Cross-sectional study. SETTING: Four U.S. sites. PARTICIPANTS: Nine thousand three hundred forty-four women aged 65 and older (mean 71.6) who self-reported teenage, age 30, age 50, and late-life physical activity. MEASUREMENTS: Logistic regression was used to determine the association between physical activity status at each age and likelihood of cognitive impairment (modified Mini-Mental State Examination (mMMSE) score >1.5 standard deviations below the mean, mMMSE score</=22). Models were adjusted for age, education, marital status, diabetes mellitus, hypertension, depressive symptoms, smoking, and body mass index. RESULTS:Women who reported being physically active had a lower prevalence of cognitive impairment in late life than women who were inactive at each time (teenage: 8.5% vs 16.7%, adjusted odds ratio (AOR)=0.65, 95% confidence interval (CI)=0.53-0.80; age 30: 8.9% vs 12.0%, AOR=0.80, 95% CI=0.67-0.96); age 50: 8.5% vs 13.1%, AOR=0.71, 95% CI=0.59-0.85; old age: 8.2% vs 15.9%, AOR=0.74, 95% CI=0.61-0.91). When the four times were analyzed together, teenage physical activity was most strongly associated with lower odds of late-life cognitive impairment (OR=0.73, 95% CI=0.58-0.92). However, women who were physically inactive as teenagers and became active in later life had lower risk than those who remained inactive. CONCLUSIONS:Women who reported being physically active at any point over the life course, especially as teenagers, had a lower likelihood of cognitive impairment in late life. Interventions should promote physical activity early in life and throughout the life course.
Authors: Sari Stenholm; Annemarie Koster; Heli Valkeinen; Kushang V Patel; Stefania Bandinelli; Jack M Guralnik; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2015-08-18 Impact factor: 6.053
Authors: Wenfei Zhu; Virginia J Howard; Virginia G Wadley; Brent Hutto; Steven N Blair; John E Vena; Natalie Colabianchi; David Rhodes; Steven P Hooker Journal: J Am Geriatr Soc Date: 2015-12 Impact factor: 5.562
Authors: Joshua Z Willey; Yeseon Park Moon; Rachel Ruder; Yuen K Cheung; Ralph L Sacco; Mitchell S V Elkind; Clinton B Wright Journal: Neuroepidemiology Date: 2013-12-03 Impact factor: 3.282
Authors: Nader Fallah; Chun L Hsu; Niousha Bolandzadeh; Jennifer Davis; B Lynn Beattie; Peter Graf; Teresa Liu-Ambrose Journal: Ann Epidemiol Date: 2013-07-03 Impact factor: 3.797
Authors: Renée F A G de Bruijn; Elisabeth M C Schrijvers; Karen A de Groot; Jacqueline C M Witteman; Albert Hofman; Oscar H Franco; Peter J Koudstaal; Mohammad Arfan Ikram Journal: Eur J Epidemiol Date: 2013-02-06 Impact factor: 8.082
Authors: Regina L Leckie; Stephen B Manuck; Neha Bhattacharjee; Matthew F Muldoon; Janine M Flory; Kirk I Erickson Journal: Neuropsychologia Date: 2014-05-09 Impact factor: 3.139
Authors: Lindsay S Nagamatsu; Leon Flicker; Arthur F Kramer; Michelle W Voss; Kirk I Erickson; Chun Liang Hsu; Teresa Liu-Ambrose Journal: Br J Sports Med Date: 2014-03-21 Impact factor: 13.800