| Literature DB >> 20608641 |
Michael D Kurland1, Michael B Newcomer, Zita Peterlin, Kevin Ryan, Stuart Firestein, Victor S Batista.
Abstract
The discrimination of n-alkyl-saturated aldehydes during the early stage of odorant recognition by the rat I7 olfactory receptor (OR-I7) is investigated. The concentrations of odorants necessary for 50% activation (or inhibition) of the OR-I7 are measured by calcium imaging recordings of dissociated rat olfactory sensory neurons, expressing the recombinant OR-I7 from an adenoviral vector. These are correlated with the corresponding binding free energies computed for a homology structural model of the OR-I7 built from the crystal structure of bovine visual rhodopsin at 2.2 A resolution.Entities:
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Year: 2010 PMID： 20608641 PMCID： PMC2912408 DOI： 10.1021/bi100976w
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162