BACKGROUND: To analyze Fetuin-A levels and soluble cellular adhesion molecules in patients with acute coronary syndrome. METHODS AND RESULTS: Serum Fetuin-A and intercellular adhesion molecule-1 (sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1) levels were examined in 127 patients who presented with chest pain. These patients were classified in three groups: stable angina (SA, n=51), myocardial infarction (MI, n=34) and non-cardiac group (n=42). Logarithmic transformations were made for Fetuin-A levels. Log-Fetuin-A levels were higher in non-cardiac subjects compared to MI and SA patients (p<0.05). Patients with SA showed lower levels than controls but higher levels as compared to MI patients. After controlling for age and gender, levels of sVCAM-1 and sICAM-1 in patients with coronary atherosclerosis were not different from those in non-cardiac subjects. CONCLUSION: Serum levels of soluble VCAM-1, ICAM-1 were not related to coronary artery disease (CAD), but fetuin-A levels seems to be decreased in SA and MI patients. Low fetuin-A may play a role in the pathophysiology of CAD.
BACKGROUND: To analyze Fetuin-A levels and soluble cellular adhesion molecules in patients with acute coronary syndrome. METHODS AND RESULTS: Serum Fetuin-A and intercellular adhesion molecule-1 (sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1) levels were examined in 127 patients who presented with chest pain. These patients were classified in three groups: stable angina (SA, n=51), myocardial infarction (MI, n=34) and non-cardiac group (n=42). Logarithmic transformations were made for Fetuin-A levels. Log-Fetuin-A levels were higher in non-cardiac subjects compared to MI and SA patients (p<0.05). Patients with SA showed lower levels than controls but higher levels as compared to MI patients. After controlling for age and gender, levels of sVCAM-1 and sICAM-1 in patients with coronary atherosclerosis were not different from those in non-cardiac subjects. CONCLUSION: Serum levels of soluble VCAM-1, ICAM-1 were not related to coronary artery disease (CAD), but fetuin-A levels seems to be decreased in SA and MI patients. Low fetuin-A may play a role in the pathophysiology of CAD.
Authors: Monik C Jiménez; Qi Sun; Markus Schürks; Frank B Hu; Joann E Manson; Kathryn M Rexrode Journal: Clin Chem Date: 2013-10-29 Impact factor: 8.327
Authors: Lindsey R Boone; William R Lagor; Margarita de la Llera Moya; Melissa I Niesen; George H Rothblat; Gene C Ness Journal: Atherosclerosis Date: 2011-05-06 Impact factor: 5.162
Authors: Yashu Liu; Toufan Parman; Bridget Schneider; Benben Song; Amit K Galande; Dave Anderson; Jon Mirsalis Journal: J Proteome Res Date: 2013-03-28 Impact factor: 4.466