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Literature DB >> 2060567

Use of a pharmacokinetic-dynamic model for the automatic feedback control of atracurium.

Abstract

A control algorithm for the closed-loop control of atracurium-induced neuromuscular blockade based on pharmacokinetic-dynamic model-based adaptive feedback is described. Mean offset from setpoint at 90% neuromuscular block was 0.04% and the mean standard deviation from mean neuromuscular block was 1.9%. The mean average atracurium requirement was 0.37 mg.kg-1.h-1. The model-based adaptive closed-loop control of atracurium infusion provided reasonable control of muscle relaxation. It offers a solution to the problem of adapting pharmacokinetic and pharmacodynamic data to individuals when using mean data as starting values for drug therapy.

Entities: Chemical

Mesh：

Substances：
Atracurium

Year: 1991 PMID： 2060567 DOI： 10.1007/bf00315212

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

11 in total

1. Automatic control of neuromuscular block with atracurium.

Authors: A D MacLeod; A J Asbury; W M Gray; D A Linkens
Journal: Br J Anaesth Date: 1989-07 Impact factor: 9.166

2. Closed-loop administration of atracurium. Steady-state neuromuscular blockade during surgery using a computer controlled closed-loop atracurium infusion.

Authors: N R Webster; A T Cohen
Journal: Anaesthesia Date: 1987-10 Impact factor: 6.955

3. Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man.

Authors: J G Wagner
Journal: J Theor Biol Date: 1968-08 Impact factor: 2.691

Use of a pharmacokinetic-dynamic model for the automatic feedback control of atracurium.

1. Automatic control of neuromuscular block with atracurium.

2. Closed-loop administration of atracurium. Steady-state neuromuscular blockade during surgery using a computer controlled closed-loop atracurium infusion.

3. Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man.

Review 4. Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application.

5. Infusion of vecuronium controlled by a closed-loop system.

6. A pharmacodynamic model for pancuronium.

7. A general method for calculating the dosage scheme in linear pharmacokinetics.

8. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine.

9. Pharmacokinetics, pharmacodynamics and dose-response relationships of atracurium administered i.v.

10. Feedback control of neuromuscular blockade. A simple system for infusion of atracurium.

1. In vivo evaluation of a closed loop monitoring strategy for induced paralysis.

2. Hierarchical rule-based monitoring and fuzzy logic control for neuromuscular block.

3. Self-learning fuzzy control of atracurium-induced neuromuscular block during surgery.

4. Hipocrates: a robust system for the control of neuromuscular blockade.

5. [Feedback control of muscle relaxation with a varying on-off controller using cisatracurium].

Review 6. Beyond Genetics-Stratified and Personalised Medicines Using Multiple Parameters.