Literature DB >> 20603072

The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.

Raga Krishnakumar1, W Lee Kraus.   

Abstract

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20603072      PMCID： PMC2923840          DOI： 10.1016/j.molcel.2010.06.017

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  160 in total

1.  Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.

Authors:  Aaron J Gottschalk; Gyula Timinszky; Stephanie E Kong; Jingji Jin; Yong Cai; Selene K Swanson; Michael P Washburn; Laurence Florens; Andreas G Ladurner; Joan W Conaway; Ronald C Conaway
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-06       Impact factor: 11.205

2.  PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation.

Authors:  Furong Gao; Sung Won Kwon; Yingming Zhao; Ying Jin
Journal:  J Biol Chem       Date:  2009-06-16       Impact factor: 5.157

3.  SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.

Authors:  Senthilkumar B Rajamohan; Vinodkumar B Pillai; Madhu Gupta; Nagalingam R Sundaresan; Konstantin G Birukov; Sadhana Samant; Michael O Hottiger; Mahesh P Gupta
Journal:  Mol Cell Biol       Date:  2009-05-26       Impact factor: 4.272

4.  Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.

Authors:  Tong Zhang; Jhoanna G Berrocal; Kristine M Frizzell; Matthew J Gamble; Michelle E DuMond; Raga Krishnakumar; Tianle Yang; Anthony A Sauve; W Lee Kraus
Journal:  J Biol Chem       Date:  2009-05-28       Impact factor: 5.157

5.  Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.

Authors:  Mauricio F Farez; Francisco J Quintana; Roopali Gandhi; Guillermo Izquierdo; Miguel Lucas; Howard L Weiner
Journal:  Nat Immunol       Date:  2009-08-16       Impact factor: 25.606

6.  Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.

Authors:  Helen E Ambrose; Shaun Willimott; Richard W Beswick; Françoise Dantzer; Josiane Ménissier de Murcia; José Yelamos; Simon D Wagner
Journal:  Immunology       Date:  2008-09-04       Impact factor: 7.397

7.  Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites.

Authors:  Matthias Altmeyer; Simon Messner; Paul O Hassa; Monika Fey; Michael O Hottiger
Journal:  Nucleic Acids Res       Date:  2009-04-16       Impact factor: 16.971

8.  Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Authors:  Peter C Fong; David S Boss; Timothy A Yap; Andrew Tutt; Peijun Wu; Marja Mergui-Roelvink; Peter Mortimer; Helen Swaisland; Alan Lau; Mark J O'Connor; Alan Ashworth; James Carmichael; Stan B Kaye; Jan H M Schellens; Johann S de Bono
Journal:  N Engl J Med       Date:  2009-06-24       Impact factor: 91.245

9.  Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

Authors:  N McCabe; M A Cerone; T Ohishi; H Seimiya; C J Lord; A Ashworth
Journal:  Oncogene       Date:  2009-02-02       Impact factor: 9.867

10.  Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing.

Authors:  Yingbiao Ji; Alexei V Tulin
Journal:  Nucleic Acids Res       Date:  2009-04-03       Impact factor: 16.971
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  379 in total

1.  Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.

Authors:  Wen-Hua Chen; Shan-Shan Song; Ming-Hui Qi; Xia-Juan Huan; Ying-Qing Wang; Hualiang Jiang; Jian Ding; Guo-Bin Ren; Ze-Hong Miao; Jian Li
Journal:  Acta Pharmacol Sin       Date:  2017-08-03       Impact factor: 6.150

Review 2.  Sirtuins mediate mammalian metabolic responses to nutrient availability.

Authors:  Angeliki Chalkiadaki; Leonard Guarente
Journal:  Nat Rev Endocrinol       Date:  2012-01-17       Impact factor: 43.330

3.  Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function.

Authors:  Süheda Erener; Mareike Hesse; Radina Kostadinova; Michael O Hottiger
Journal:  Mol Endocrinol       Date:  2011-11-03

4.  Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.

Authors:  Zhizhi Wang; Gregory A Michaud; Zhihong Cheng; Yue Zhang; Thomas R Hinds; Erkang Fan; Feng Cong; Wenqing Xu
Journal:  Genes Dev       Date:  2012-01-19       Impact factor: 11.361

Review 5.  Molecular mechanisms and potential functions of histone demethylases.

Authors:  Susanne Marije Kooistra; Kristian Helin
Journal:  Nat Rev Mol Cell Biol       Date:  2012-04-04       Impact factor: 94.444

6.  Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase.

Authors:  Tong Zhang; Jhoanna G Berrocal; Jie Yao; Michelle E DuMond; Raga Krishnakumar; Donald D Ruhl; Keun Woo Ryu; Matthew J Gamble; W Lee Kraus
Journal:  J Biol Chem       Date:  2012-02-13       Impact factor: 5.157

7.  The ups and downs of DNA repair biomarkers for PARP inhibitor therapies.

Authors:  Xiaozhe Wang; David T Weaver
Journal:  Am J Cancer Res       Date:  2010-01-03       Impact factor: 6.166

Review 8.  More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance.

Authors:  Jiri Lukas; Claudia Lukas; Jiri Bartek
Journal:  Nat Cell Biol       Date:  2011-10-03       Impact factor: 28.824

9.  BCL2 suppresses PARP1 function and nonapoptotic cell death.

Authors:  Chaitali Dutta; Tovah Day; Nadja Kopp; Diederik van Bodegom; Matthew S Davids; Jeremy Ryan; Liat Bird; Naveen Kommajosyula; Oliver Weigert; Akinori Yoda; Hua Fung; Jennifer R Brown; Geoffrey I Shapiro; Anthony Letai; David M Weinstock
Journal:  Cancer Res       Date:  2012-06-11       Impact factor: 12.701

10.  Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro.

Authors:  Robert L Dilley; Weijie Poh; Douglas E Gladstone; James G Herman; Margaret M Showel; Judith E Karp; Michael A McDevitt; Keith W Pratz
Journal:  Leuk Res       Date:  2013-12-30       Impact factor: 3.156
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