Literature DB >> 20600921

V(D)J recombination: Born to be wild.

Dale A Ramsden1, Brett D Weed, Yeturu V R Reddy.   

Abstract

Vertebrates employ V(D)J recombination to generate diversity for an adaptive immune response. Born of a transposon, V(D)J recombination could conceivably cause more trouble than its worth. However, of the two steps required for transposon mobility (excision and integration) this particular transposon's integration step appears mostly blocked in cells. The employment of a transposon as raw material to develop adaptive immunity was thus a less-risky choice than it might have been … but is it completely risk-free?
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20600921      PMCID： PMC2942997          DOI： 10.1016/j.semcancer.2010.06.002

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  42 in total

Review 1.  V(D)J recombination: links to transposition and double-strand break repair.

Authors:  M Gellert; J E Hesse; K Hiom; M Melek; M Modesti; T T Paull; D A Ramsden; D C van Gent
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1999

2.  Targeted transposition by the V(D)J recombinase.

Authors:  Gregory S Lee; Matthew B Neiditch; Richard R Sinden; David B Roth
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

3.  The V(D)J recombinase efficiently cleaves and transposes signal joints.

Authors:  Matthew B Neiditch; Gregory S Lee; Leslie E Huye; Vicky L Brandt; David B Roth
Journal:  Mol Cell       Date:  2002-04       Impact factor: 17.970

4.  Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2.

Authors:  Chia-Lun Tsai; David G Schatz
Journal:  EMBO J       Date:  2003-04-15       Impact factor: 11.598

5.  The C-terminal portion of RAG2 protects against transposition in vitro.

Authors:  Sheryl K Elkin; Adam G Matthews; Marjorie A Oettinger
Journal:  EMBO J       Date:  2003-04-15       Impact factor: 11.598

6.  Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

Authors:  Rodrig Marculescu; Katrina Vanura; Trang Le; Paul Simon; Ulrich Jäger; Bertrand Nadel
Journal:  Nat Genet       Date:  2003-02-03       Impact factor: 38.330

7.  Dynamic roles for G4 DNA in the biology of eukaryotic cells.

Authors:  Nancy Maizels
Journal:  Nat Struct Mol Biol       Date:  2006-12       Impact factor: 15.369

8.  In vivo transposition mediated by V(D)J recombinase in human T lymphocytes.

Authors:  Terri L Messier; J Patrick O'Neill; Sai-Mei Hou; Janice A Nicklas; Barry A Finette
Journal:  EMBO J       Date:  2003-03-17       Impact factor: 11.598

9.  RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences.

Authors:  M Melek; M Gellert
Journal:  Cell       Date:  2000-06-09       Impact factor: 41.582

10.  Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

Authors:  J A Sekiguchi; S Whitlow; F W Alt
Journal:  Mol Cell       Date:  2001-12       Impact factor: 17.970
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  9 in total

1.  Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Authors:  Dylan A Reid; Sarah Keegan; Alejandra Leo-Macias; Go Watanabe; Natasha T Strande; Howard H Chang; Betul Akgol Oksuz; David Fenyo; Michael R Lieber; Dale A Ramsden; Eli Rothenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

2.  The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.

Authors:  Jose Ricardo Morales Poole; Sheng Feng Huang; Anlong Xu; Justine Bayet; Pierre Pontarotti
Journal:  Immunogenetics       Date:  2017-04-28       Impact factor: 2.846

Review 3.  Useful parasites: the evolutionary biology and biotechnology applications of transposable elements.

Authors:  Georgi N Bonchev
Journal:  J Genet       Date:  2016-12       Impact factor: 1.166

Review 4.  Diversity of Immunoglobulin (Ig) Isotypes and the Role of Activation-Induced Cytidine Deaminase (AID) in Fish.

Authors:  Bhakti Patel; Rajanya Banerjee; Mrinal Samanta; Surajit Das
Journal:  Mol Biotechnol       Date:  2018-06       Impact factor: 2.695

5.  Chromosome organization affects genome evolution in Sulfolobus archaea.

Authors:  Catherine Badel; Rachel Y Samson; Stephen D Bell
Journal:  Nat Microbiol       Date:  2022-05-26       Impact factor: 30.964

6.  Mechanisms for Structural Variation in the Human Genome.

Authors:  Benjamin B Currall; C Chiang; Michael E Talkowski; Cynthia C Morton
Journal:  Curr Genet Med Rep       Date:  2013-06-01

Review 7.  Preserving genome integrity in human cells via DNA double-strand break repair.

Authors:  Ryan B Jensen; Eli Rothenberg
Journal:  Mol Biol Cell       Date:  2020-04-15       Impact factor: 4.138

8.  Elevated expression of artemis in human fibroblast cells is associated with cellular radiosensitivity and increased apoptosis.

Authors:  G Ulus-Senguloglu; C F Arlett; P N Plowman; J Parnell; N Patel; E C Bourton; C N Parris
Journal:  Br J Cancer       Date:  2012-10-23       Impact factor: 7.640

9.  More than one antibody of individual B cells revealed by single-cell immune profiling.

Authors:  Zhan Shi; Qingyang Zhang; Huige Yan; Ying Yang; Pingzhang Wang; Yixiao Zhang; Zhenling Deng; Meng Yu; Wenjing Zhou; Qianqian Wang; Xi Yang; Xiaoning Mo; Chi Zhang; Jing Huang; Hui Dai; Baofa Sun; Yongliang Zhao; Liang Zhang; Yun-Gui Yang; Xiaoyan Qiu
Journal:  Cell Discov       Date:  2019-12-10       Impact factor: 10.849
  9 in total

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