OBJECTIVE: To evaluate the relationship between pesticide use and myocardial infarction (MI) among farm women. BACKGROUND: Little is known about the potential association between pesticide use and cardiovascular outcomes. METHODS: We used logistic regression to evaluate pesticide use and self-reported incident nonfatal MI among women in the Agricultural Health Study. RESULTS: Of those MI-free at enrollment (n = 22,425), 168 reported an MI after enrollment. We saw no association with pesticide use overall. Six of 27 individual pesticides evaluated were significantly associated with nonfatal MI, including chlorpyrifos, coumaphos, carbofuran, metalaxyl, pendimethalin, and trifluralin, which all had odds ratios >1.7. These chemicals were used by <10% of the cases, and their use was correlated, making it difficult to attribute the risk elevation to a specific pesticide. CONCLUSION: Pesticides may contribute to MI risk among farm women.
OBJECTIVE: To evaluate the relationship between pesticide use and myocardial infarction (MI) among farm women. BACKGROUND: Little is known about the potential association between pesticide use and cardiovascular outcomes. METHODS: We used logistic regression to evaluate pesticide use and self-reported incident nonfatal MI among women in the Agricultural Health Study. RESULTS: Of those MI-free at enrollment (n = 22,425), 168 reported an MI after enrollment. We saw no association with pesticide use overall. Six of 27 individual pesticides evaluated were significantly associated with nonfatal MI, including chlorpyrifos, coumaphos, carbofuran, metalaxyl, pendimethalin, and trifluralin, which all had odds ratios >1.7. These chemicals were used by <10% of the cases, and their use was correlated, making it difficult to attribute the risk elevation to a specific pesticide. CONCLUSION: Pesticides may contribute to MI risk among farm women.
Authors: Aaron Blair; Robert Tarone; Dale Sandler; Charles F Lynch; Andrew Rowland; Wendy Wintersteen; William C Steen; Claudine Samanic; Mustafa Dosemeci; Michael C R Alavanja Journal: Epidemiology Date: 2002-01 Impact factor: 4.822
Authors: John K Ninomiya; Gilbert L'Italien; Michael H Criqui; Joanna L Whyte; Anthony Gamst; Roland S Chen Journal: Circulation Date: 2003-12-15 Impact factor: 29.690
Authors: Katherine T Mills; Aaron Blair; Laura E Beane Freeman; Dale P Sandler; Jane A Hoppin Journal: Am J Epidemiol Date: 2009-08-21 Impact factor: 4.897
Authors: Yu-Han Chiu; Helena Sandoval-Insausti; Sylvia H Ley; Shilpa N Bhupathiraju; Russ Hauser; Eric B Rimm; JoAnn E Manson; Qi Sun; Jorge E Chavarro Journal: Environ Int Date: 2019-08-29 Impact factor: 9.621
Authors: Cynthia F Robinson; James T Walker; Marie H Sweeney; Rui Shen; Geoffrey M Calvert; Pam K Schumacher; Jun Ju; Susan Nowlin Journal: Am J Ind Med Date: 2015-02 Impact factor: 2.214
Authors: Jill F Lebov; Lawrence S Engel; David Richardson; Susan L Hogan; Dale P Sandler; Jane A Hoppin Journal: Environ Res Date: 2015-10-24 Impact factor: 6.498
Authors: Zara K Berg; Beatriz Rodriguez; James Davis; Alan R Katz; Robert V Cooney; Kamal Masaki Journal: J Am Heart Assoc Date: 2019-09-25 Impact factor: 5.501
Authors: Miguel Alfonso Ruíz-Arias; Irma Martha Medina-Díaz; Yael Yvette Bernal-Hernández; Juan Manuel Agraz-Cibrián; Cyndia Azucena González-Arias; Briscia Socorro Barrón-Vivanco; José Francisco Herrera-Moreno; Francisco Alberto Verdín-Betancourt; José Francisco Zambrano-Zaragoza; Aurora Elizabeth Rojas-García Journal: Environ Sci Pollut Res Int Date: 2022-10-14 Impact factor: 5.190
Authors: Melissa S Burroughs Peña; Jean Claude Uwamungu; Catherine M Bulka; Katrina Swett; Krista M Perreira; Mayank M Kansal; Matthew Shane Loop; Barry E Hurwitz; Martha Daviglus; Carlos J Rodriguez Journal: J Am Heart Assoc Date: 2020-08-26 Impact factor: 5.501