| Literature DB >> 20594843 |
Min Xie1, Ravi K Ujjinamatada, Mariola Sadowska, Rena G Lapidus, Martin J Edelman, Ramachandra S Hosmane.
Abstract
Synthesis and broad-spectrum anticancer activity of a novel heterocyclic compound 1 containing the title imidazo[4,5-e][1,3]diazepine ring system have been reported. The compound shows potent in vitro antitumor activity with low micromolar IC(50)'s against prostate, lung, breast, and ovarian cancer cell lines tested. The long alkyl chain attached to the six-position of the heterocyclic ring of 1 appears to be necessary for the observed biological activity. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20594843 PMCID： PMC2905507 DOI： 10.1016/j.bmcl.2010.06.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823