| Literature DB >> 20588300 |
Satoshi Sasamura1, Kazutoshi Sakamoto, Shoji Takagaki, Toshiko Yamada, Shigehiro Takase, Hiroaki Mori, Takashi Fujii, Motohiro Hino, Michizane Hashimoto.
Abstract
The novel immunosuppressant AS1387392 has been isolated from Acremonium sp. No. 27082. This compound showed a strong inhibitory effect against mammalian histone deacetylase and T-cell proliferation. Further, AS1387392 showed a good oral absorption, and its plasma concentration was higher than that of FR235222, an analog of AS1387392 that inhibited histone deacetylase previously reported. Given these findings, AS1387392 may represent an important new lead in developing immunosuppressant.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20588300 DOI： 10.1038/ja.2010.51
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649