Literature DB >> 20582620

Towards the development of hemerythrin-based blood substitutes.

Augustin C Mot1, Alina Roman, Iulia Lupan, Donald M Kurtz, Radu Silaghi-Dumitrescu.   

Abstract

Hemerythrin is proposed as an alternative to hemoglobin-based blood substitutes. In contrast to hemoglobin, hemerythrin exhibits negligible reactivity towards oxidative and nitrosative stress agents (peroxide, nitric oxide, nitrite). Protocols for attachment of polyethylene glycol and glutaraldehyde cross-linking of Hr are described. These derivatizations appear to have favorable effects on O(2) affinity and autoxidation rates for use in blood substitutes. Based on lessons learned from hemoglobin-based blood substitutes, these derivatizations should also help limit extravasation and antigenicity of a hemerythrin-based blood substitute.

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Year:  2010        PMID： 20582620     DOI： 10.1007/s10930-010-9264-2

Source DB:  PubMed          Journal:  Protein J        ISSN： 1572-3887            Impact factor:   2.371


  28 in total

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  6 in total

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