Literature DB >> 20581877

Fungal pathogenicity and morphological switches.

P T Magee.   

Abstract

The virulence of Candida albicans, a major human fungal pathogen, has been considered dependent on the ability to transition between different morphologies. A new study reports a screen of C. albicans mutants that demonstrates that pathogenesis can be dissociated from morphological switching and in vitro growth rate.

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Year:  2010        PMID： 20581877     DOI： 10.1038/ng0710-560

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

Review 1.  Signature-tagged mutagenesis in the identification of virulence genes in pathogens.

Authors:  J E Shea; J D Santangelo; R G Feldman
Journal:  Curr Opin Microbiol       Date:  2000-10       Impact factor: 7.934

2.  Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis.

Authors:  C Csank; K Schröppel; E Leberer; D Harcus; O Mohamed; S Meloche; D Y Thomas; M Whiteway
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

3.  Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans.

Authors:  C R Rocha; K Schröppel; D Harcus; A Marcil; D Dignard; B N Taylor; D Y Thomas; M Whiteway; E Leberer
Journal:  Mol Biol Cell       Date:  2001-11       Impact factor: 4.138

4.  Function of Candida albicans adhesin Hwp1 in biofilm formation.

Authors:  Clarissa J Nobile; Jeniel E Nett; David R Andes; Aaron P Mitchell
Journal:  Eukaryot Cell       Date:  2006-10

5.  Role of hyphal formation in interactions of Candida albicans with endothelial cells.

Authors:  Q T Phan; P H Belanger; S G Filler
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

Review 6.  Genetics and genomics of Candida albicans biofilm formation.

Authors:  Clarissa J Nobile; Aaron P Mitchell
Journal:  Cell Microbiol       Date:  2006-07-11       Impact factor: 3.715

7.  Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.

Authors:  Suzanne M Noble; Sarah French; Lisa A Kohn; Victoria Chen; Alexander D Johnson
Journal:  Nat Genet       Date:  2010-06-13       Impact factor: 38.330

8.  Transcriptional response of Candida albicans upon internalization by macrophages.

Authors:  Michael C Lorenz; Jennifer A Bender; Gerald R Fink
Journal:  Eukaryot Cell       Date:  2004-10

9.  Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies.

Authors:  J Lay; L K Henry; J Clifford; Y Koltin; C E Bulawa; J M Becker
Journal:  Infect Immun       Date:  1998-11       Impact factor: 3.441

10.  Invasion process of Candida albicans to tongue surface in early stages of experimental murine oral candidiasis.

Authors:  T Hisajima; H Ishibashi; T Yamada; Y Nishiyama; H Yamaguchi; K Funakoshi; S Abe
Journal:  Med Mycol       Date:  2008-11       Impact factor: 4.076
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  2 in total

1.  Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype.

Authors:  J Schmid; A M Tortorano; G Jones; C Lazzarini; N Zhang; M J Bendall; M Cogliati; S Wattimena; L Klingspor
Journal:  J Clin Microbiol       Date:  2011-07-20       Impact factor: 5.948

2.  Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.

Authors:  Sarah Saputo; Anuj Kumar; Damian J Krysan
Journal:  Eukaryot Cell       Date:  2014-07-07
  2 in total

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