Literature DB >> 11050441

Signature-tagged mutagenesis in the identification of virulence genes in pathogens.

J E Shea1, J D Santangelo, R G Feldman.   

Abstract

Signature-tagged mutagenesis is a functional genomics technique that identifies microbial genes required for infection within an animal host, or within host cells. The application of this technique to a range of microbial pathogens has resulted in the identification of novel virulence determinants in each screen performed to date, so that cumulatively several hundred genes have been ascribed a role in virulence.

Mesh：

Year:  2000        PMID： 11050441     DOI： 10.1016/s1369-5274(00)00120-x

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  24 in total

Review 1.  New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae.

Authors:  Anne Marie Di Guilmi; Andréa Dessen
Journal:  EMBO Rep       Date:  2002-08       Impact factor: 8.807

2.  Construction of a large signature-tagged mini-Tn5 transposon library and its application to mutagenesis of Sinorhizobium meliloti.

Authors:  Nataliya Pobigaylo; Danijel Wetter; Silke Szymczak; Ulf Schiller; Stefan Kurtz; Folker Meyer; Tim W Nattkemper; Anke Becker
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

3.  Identification of Aeromonas veronii genes required for colonization of the medicinal leech, Hirudo verbana.

Authors:  Adam C Silver; Natasha M Rabinowitz; Stefan Küffer; Joerg Graf
Journal:  J Bacteriol       Date:  2007-07-06       Impact factor: 3.490

4.  Novel attenuated Salmonella enterica serovar Choleraesuis strains as live vaccine candidates generated by signature-tagged mutagenesis.

Authors:  Yu-We Ku; Sean P McDonough; Raghavan U M Palaniappan; Chao-Fu Chang; Yung-Fu Chang
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

5.  Identification of Actinobacillus suis genes essential for the colonization of the upper respiratory tract of swine.

Authors:  Shivani Ojha; Marc Sirois; Janet I Macinnes
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

6.  Two-component systems of Helicobacter pylori contribute to virulence in a mouse infection model.

Authors:  Klaus Panthel; Patricia Dietz; Rainer Haas; Dagmar Beier
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

7.  Identification of novel virulence-associated genes via genome analysis of hypothetical genes.

Authors:  Sara Garbom; Ake Forsberg; Hans Wolf-Watz; Britt-Marie Kihlberg
Journal:  Infect Immun       Date:  2004-03       Impact factor: 3.441

8.  Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.

Authors:  Suzanne M Noble; Sarah French; Lisa A Kohn; Victoria Chen; Alexander D Johnson
Journal:  Nat Genet       Date:  2010-06-13       Impact factor: 38.330

9.  Genome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and Plasma.

Authors:  Luchang Zhu; Prasanti Yerramilli; Layne Pruitt; Matthew Ojeda Saavedra; Concepcion C Cantu; Randall J Olsen; Stephen B Beres; Andrew S Waller; James M Musser
Journal:  Infect Immun       Date:  2020-09-18       Impact factor: 3.441

10.  RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium.

Authors:  Emily Hart; Ji Yang; Marija Tauschek; Michelle Kelly; Matthew J Wakefield; Gad Frankel; Elizabeth L Hartland; Roy M Robins-Browne
Journal:  Infect Immun       Date:  2008-09-02       Impact factor: 3.441
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