| Literature DB >> 20580290 |
Karen Blyth1, Francois Vaillant, Alma Jenkins, Laura McDonald, Marie Anne Pringle, Camille Huser, Torsten Stein, James Neil, Ewan R Cameron.
Abstract
The Runx transcription factors are essential for mammalian development, most notably in the haematopoietic and osteogenic lineages. Runx1 and its binding partner, CBFbeta, are frequently targeted in acute leukaemia but evidence is accumulating that all three Runx genes may have a role to play in a wider range of cancers, either as tumour promoters or tumour suppressors. Whilst Runx2 is renowned for its role as a master regulator of bone development we discuss here its expression pattern and putative functions beyond this lineage. Furthermore, we review the evidence that RUNX2 promotes neoplastic development in haematopoietic lineages and in advanced mammary and prostate cancer. 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20580290 DOI： 10.1016/j.bcmd.2010.05.007
Source DB: PubMed Journal: Blood Cells Mol Dis ISSN： 1079-9796 Impact factor: 3.039