CONTEXT: Previous research has shown that the effectiveness of acupressure bands in reducing chemotherapy-related nausea is related to patients' expectations of efficacy. OBJECTIVE: To test whether an informational manipulation designed to increase expectation of efficacy regarding acupressure bands would enhance their effectiveness. METHODS: We conducted an exploratory, four-arm, randomized clinical trial in breast cancer patients about to begin chemotherapy. All patients received acupressure bands and a relaxation CD. This report focuses on Arm 1(expectancy-neutral informational handout and CD) compared with Arm 4 (expectancy-enhancing handout and CD). Randomization was stratified according to the patient's level of certainty that she would have treatment-induced nausea (two levels: high and low). Experience of nausea and use of antiemetics were assessed with a five-day diary. RESULTS: Our expectancy-enhancing manipulation resulted in improved control of nausea in the 26 patients with high nausea expectancies but lessened control of nausea in 27 patients having low nausea expectancies. This interaction effect (between expected nausea and intervention effectiveness) approached statistical significance for our analysis of average nausea (P=0.084) and reached statistical significance for our analysis of peak nausea (P=0.030). Patients receiving the expectancy-enhancing manipulation took fewer antiemetic pills outside the clinic (mean(enhanced)=12.6; mean(neutral)=18.5, P=0.003). CONCLUSION: This exploratory intervention reduced antiemetic use overall and also reduced nausea in patients who had high levels of expected nausea. Interestingly, it increased nausea in patients who had low expectancies for nausea. Confirmatory research is warranted. 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
RCT Entities:
CONTEXT: Previous research has shown that the effectiveness of acupressure bands in reducing chemotherapy-related nausea is related to patients' expectations of efficacy. OBJECTIVE: To test whether an informational manipulation designed to increase expectation of efficacy regarding acupressure bands would enhance their effectiveness. METHODS: We conducted an exploratory, four-arm, randomized clinical trial in breast cancerpatients about to begin chemotherapy. All patients received acupressure bands and a relaxation CD. This report focuses on Arm 1(expectancy-neutral informational handout and CD) compared with Arm 4 (expectancy-enhancing handout and CD). Randomization was stratified according to the patient's level of certainty that she would have treatment-induced nausea (two levels: high and low). Experience of nausea and use of antiemetics were assessed with a five-day diary. RESULTS: Our expectancy-enhancing manipulation resulted in improved control of nausea in the 26 patients with high nausea expectancies but lessened control of nausea in 27 patients having low nausea expectancies. This interaction effect (between expected nausea and intervention effectiveness) approached statistical significance for our analysis of average nausea (P=0.084) and reached statistical significance for our analysis of peak nausea (P=0.030). Patients receiving the expectancy-enhancing manipulation took fewer antiemetic pills outside the clinic (mean(enhanced)=12.6; mean(neutral)=18.5, P=0.003). CONCLUSION: This exploratory intervention reduced antiemetic use overall and also reduced nausea in patients who had high levels of expected nausea. Interestingly, it increased nausea in patients who had low expectancies for nausea. Confirmatory research is warranted. 2010 U.S. CancerPain Relief Committee. Published by Elsevier Inc. All rights reserved.
Authors: Alexander Molassiotis; Hilary P Yung; Bernard M C Yam; Flora Y S Chan; T S K Mok Journal: Support Care Cancer Date: 2001-12-18 Impact factor: 3.603
Authors: Joseph A Roscoe; Peter Bushunow; Gary R Morrow; Jane T Hickok; Philip J Kuebler; Andrew Jacobs; Tarit K Banerjee Journal: Cancer Date: 2004-12-01 Impact factor: 6.860
Authors: Jane T Hickok; Joseph A Roscoe; Gary R Morrow; David K King; James N Atkins; Tom R Fitch Journal: Cancer Date: 2003-06-01 Impact factor: 6.860
Authors: Joseph A Roscoe; Gary R Morrow; Jane T Hickok; Peter Bushunow; H Irving Pierce; Patrick J Flynn; Jeffrey J Kirshner; Dennis F Moore; James N Atkins Journal: J Pain Symptom Manage Date: 2003-08 Impact factor: 3.612
Authors: Anita R Peoples; Eva Culakova; Charles E Heckler; Michelle Shayne; Tracey L O'Connor; Jeffrey J Kirshner; Peter W Bushunow; Gary R Morrow; Joseph A Roscoe Journal: Support Care Cancer Date: 2019-03-30 Impact factor: 3.603
Authors: Charles Kamen; Mohamedtaki A Tejani; Kavita Chandwani; Michelle Janelsins; Anita R Peoples; Joseph A Roscoe; Gary R Morrow Journal: Eur J Pharmacol Date: 2013-10-21 Impact factor: 4.432
Authors: Karen M Mustian; Katie Devine; Julie L Ryan; Michelle C Janelsins; Lisa K Sprod; Luke J Peppone; Grace D Candelario; Supriya G Mohile; Gary R Morrow Journal: US Oncol Hematol Date: 2011
Authors: Karin Meissner; Nicola Talsky; Elisabeth Olliges; Carmen Jacob; Oliver J Stötzer; Christoph Salat; Michael Braun; Raluca Flondor Journal: Front Pharmacol Date: 2019-04-25 Impact factor: 5.810