PURPOSE: To determine whether progressive supranuclear palsy (PSP) is associated with specific diffusion tensor imaging (DTI) patterns of diffusivity, anisotropy, and coherence in functionally relevant brain areas. MATERIALS AND METHODS: In all, 17 PSP patients and 17 controls were scanned using a 3 T magnetic resonance imaging (MRI) scanner. Patients were assessed in the off-medication condition using the Hoehn and Yahr staging and the United Parkinson's Disease Rating Scale, motor subscale (UPDRS-III). Diffusion information were analyzed in relation to disease severity and subtypes. RESULTS: Numerous changes in diffusion properties were identified in the subcortical areas. In the midbrain, fractional anisotropy (FA) decreased and MD (mean diffusivity) increased with disease progression. UPDRS-III scores correlated positively with both FA in the caudate and MD in the pons. DTI analysis of disease subtypes demonstrated significant differences between PSP-Parkinsonism and Steele-Richardson-Olszewski syndrome in axial diffusivity values in the putamen and globus pallidus, as well as in intervoxel diffusion coherence values in the middle cerebellar peduncle. CONCLUSION: Our findings, cautiously interpreted, demonstrate the advantage of using a functional imaging technique to aid in the specificity of defining more precisely the pathological processes taking place in white and gray matter regions in PSP.
PURPOSE: To determine whether progressive supranuclear palsy (PSP) is associated with specific diffusion tensor imaging (DTI) patterns of diffusivity, anisotropy, and coherence in functionally relevant brain areas. MATERIALS AND METHODS: In all, 17 PSPpatients and 17 controls were scanned using a 3 T magnetic resonance imaging (MRI) scanner. Patients were assessed in the off-medication condition using the Hoehn and Yahr staging and the United Parkinson's Disease Rating Scale, motor subscale (UPDRS-III). Diffusion information were analyzed in relation to disease severity and subtypes. RESULTS: Numerous changes in diffusion properties were identified in the subcortical areas. In the midbrain, fractional anisotropy (FA) decreased and MD (mean diffusivity) increased with disease progression. UPDRS-III scores correlated positively with both FA in the caudate and MD in the pons. DTI analysis of disease subtypes demonstrated significant differences between PSP-Parkinsonism and Steele-Richardson-Olszewski syndrome in axial diffusivity values in the putamen and globus pallidus, as well as in intervoxel diffusion coherence values in the middle cerebellar peduncle. CONCLUSION: Our findings, cautiously interpreted, demonstrate the advantage of using a functional imaging technique to aid in the specificity of defining more precisely the pathological processes taking place in white and gray matter regions in PSP.
Authors: Edward Ofori; Florian Krismer; Roxana G Burciu; Ofer Pasternak; Johanna L McCracken; Mechelle M Lewis; Guangwei Du; Nikolaus R McFarland; Michael S Okun; Werner Poewe; Christoph Mueller; Elke R Gizewski; Michael Schocke; Christian Kremser; Hong Li; Xuemei Huang; Klaus Seppi; David E Vaillancourt Journal: Mov Disord Date: 2017-07-17 Impact factor: 10.338
Authors: G Nicoletti; M E Caligiuri; A Cherubini; M Morelli; F Novellino; G Arabia; M Salsone; A Quattrone Journal: AJNR Am J Neuroradiol Date: 2016-12-29 Impact factor: 3.825
Authors: Weihong Yuan; Kelley E Deren; James P McAllister; Scott K Holland; Diana M Lindquist; Alessandro Cancelliere; Melissa Mason; Ahmed Shereen; Dean A Hertzler; Mekibib Altaye; Francesco T Mangano Journal: Cerebrospinal Fluid Res Date: 2010-11-05