Literature DB >> 20576329

3-Formylchromones: potential antiinflammatory agents.

Khalid M Khan1, Nida Ambreen, Uzma Rasool Mughal, Saima Jalil, Shahnaz Perveen, M Iqbal Choudhary.   

Abstract

The synthesis and characterization of 3-formylchromone (1) and its derivatives 2-24 and evaluation of their potential antiinflammatory activities is reported here. These compounds were characterized by (1)H NMR, EI MS, IR, and UV spectroscopic techniques and elemental analysis. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity and their effects were compared with known standard drug such as aspirin and indomethacin. Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities. The results and SAR has been discussed in this report. 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20576329     DOI： 10.1016/j.ejmech.2010.05.065

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  21 in total

1.  3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.

Authors:  Vivek R Yadav; Sahdeo Prasad; Subash C Gupta; Bokyung Sung; Sharangdhar S Phatak; Shuxing Zhang; Bharat B Aggarwal
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

2.  Design, synthesis and evaluation of new chromone-derived aminophosphonates as potential acetylcholinesterase inhibitor.

Authors:  Sarfaraz Shaikh; Pratik Dhavan; M M V Ramana; B L Jadhav
Journal:  Mol Divers       Date:  2020-03-02       Impact factor: 2.943

3.  Copper(II) and oxidovanadium(IV) complexes of chromone Schiff bases as potential anticancer agents.

Authors:  Patrique Nunes; Yasemin Yildizhan; Zelal Adiguzel; Fernanda Marques; João Costa Pessoa; Ceyda Acilan; Isabel Correia
Journal:  J Biol Inorg Chem       Date:  2021-11-24       Impact factor: 3.358

4.  Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies.

Authors:  B Kulkarni; K Manjunatha; Muthipeedika Nibin Joy; Ayyiliath Meleveetil Sajith; Sougata Santra; Grigory V Zyryanov; C N Prashantha; Mohammed B Alshammari; K Sunil
Journal:  Mol Divers       Date:  2022-10-11       Impact factor: 3.364

5.  (4S*)-2-Methyl-amino-3-nitro-4-(4-nitro-phen-yl)-5,6,7,8-tetra-hydro-4H-chromen-5-one.

Authors:  P Narayanan; Jayabal Kamalraja; Paramasivam T Perumal; K Sethusankar
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-08-03

6.  4-(4-Bromo-phen-yl)-2-methyl-amino-3-nitro-5,6,7,8-tetra-hydro-4H-chromen-5-one.

Authors:  P Narayanan; Jayabal Kamalraja; Paramasivam T Perumal; K Sethusankar
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-22

7.  4-Hy-droxy-3-[(4-hy-droxy-6,7-dimethyl-2-oxo-2H-chromen-3-yl)(4-oxo-4H-chromen-3-yl)meth-yl]-6,7-dimethyl-2H-chromen-2-one.

Authors:  Mohammad Asad; Chuan-Wei Oo; Hasnah Osman; Chin Sing Yeap; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-20

8.  Ethyl (E)-3-(6-methyl-4-oxo-4H-chromen-3-yl)prop-2-enoate.

Authors:  Sammer Yousuf; Asma Mukhtar; Nida Ambreen; Syed Muhammad Saad; Khalid M Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-19

9.  rac-4-(4-Chloro-phen-yl)-2-methyl-amino-3-nitro-5,6,7,8-tetra-hydro-4H-chromen-5-one.

Authors:  P Narayanan; Jayabal Kamalraja; Paramasivam T Perumal; K Sethusankar
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-06-08

10.  6-Methyl-4-oxo-4H-chromene-3-carbaldehyde.

Authors:  Sammer Yousuf; Asma Mukhtar; Nida Ambreen; Syed Muhammad Saad; Khalid M Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-12
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